Self-Emulsifying Drug Delivery Systems (SEDDS): Measuring Energy Dynamics to Determine Thermodynamic and Kinetic Stability

    August 2022 in “ Pharmaceuticals ”
    Fiza Ur Rehman, A. Farid, Shefaat Ullah Shah, Muhammad Halmi Dar, Asim Ur Rehman, Naveed Ahmed, Abdur Rashid, Irfan Shaukat, Muddaser Shah, Ghadeer M. Albadrani, Mohamed S. Kamel, Ahmed E. Altyar, Mohamed M. Abdel-Daim, Kifayat Ullah Shah
    TLDR Solidified SEDDS improve drug stability and bioavailability better than liquid SEDDS.
    The study investigates the thermodynamic and kinetic stability of Self-Emulsifying Drug Delivery Systems (SEDDS) for finasteride, using energy dynamics to differentiate between stable and unstable systems. It found that many previously considered stable systems were actually unstable. The research developed and tested solidified SEDDS (S-SNEDDS) in vivo on albino rats, showing a three-fold increase in bioavailability compared to commercial tablets. Stability tests over six months indicated that S-SNEDDS are more stable than liquid SEDDS (L-SNEDDS). The study concludes that SEDDS, particularly S-SNEDDS, offer promising stability and enhanced drug delivery performance, highlighting their potential to improve the bioavailability of poorly water-soluble drugs like finasteride.
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