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This review explores the role of fatty acids and bioactive lipid mediators in skin health and suggests targeting this metabolic network to control inflammation and improve skin conditions, but it reports no new findings.

This article reviews the role of skin surface lipid in mediating environmental stressors and discusses potential therapeutic interventions, reporting no new experimental findings.

In this study, bovine milk-derived oligosaccharides were found to increase sebocyte proliferation, lipid content, and inflammatory mediator synthesis through the mTORC1 pathway, potentially contributing to milk-based inflammation in sebocytes.

This study found that isolated human scalp hair follicles express PGE2 genes and EP2 protein, suggesting PGE2 may play a crucial role in regulating hair growth.

This review synthesizes current research on PPAR-γ signaling in hair follicle biology and its potential role in treating hair growth disorders like scarring alopecia and hirsutism, but reports no new clinical results.

This study suggests that the Anetholea anisita extract improved scalp health by increasing specialized pro-resolving mediators and reducing pro-inflammatory markers, leading to decreased dandruff and enhanced hair brightness in dandruff sufferers.

In this study, researchers performed the first integrated transcriptomic and proteomic analysis of scalp biopsies from male androgenetic alopecia patients, finding a significant association between PPAR signaling pathways and AGA, with ME1 identified as a key regulator in this process.

This article discusses the potential of phospholipase A2 inhibition as a therapeutic strategy for inflammatory skin diseases and emphasizes the need for further exploration of its role and administration methods.

Genetic mutations cause various hair diseases, and whole genome sequencing may reveal more about these conditions.

This study found that fermented red ginseng marc alleviated skin lesions, reduced inflammation, and demonstrated antioxidant effects in an AD-like mouse model, suggesting potential therapeutic applications for atopic dermatitis.

This study found that TRPV3 activation in human sebocytes inhibits lipid synthesis and triggers proinflammatory cytokine expression, suggesting a role in the pathogenesis of dry skin-associated inflammatory dermatoses.

This study found that the protein C4BPA may link insulin resistance and acne vulgaris by influencing lipid metabolism and inflammatory pathways, suggesting it as a potential mediator in the pathogenesis of both conditions.

This review summarizes recent discoveries of GPCRs for lysophosphatidylserine and lysophosphatidylinositol, detailing their roles as lipid mediators, but reports no new experimental results.

This study found that skin bacteria promote regeneration in wound-induced hair follicle neogenesis, suggesting a role for IL-1β signaling and challenging the belief that infection inhibits healing.

This study observed that inducible deletion of the Ugcg gene in mouse epidermis led to a significant reduction in GlcCers and epidermal POS-Cers, causing impaired skin barrier function and delayed wound healing.

This article reviews sebaceous immunobiology and highlights the complex role of sebaceous glands and sebocytes in skin barrier function and inflammation, particularly in acne pathogenesis, but reports no new results.

This review discusses the role of regulatory T cells, highlighting recent research on how prostanoids may modulate their function, but it reports no new findings.

This review discusses the role of PPARs in skin health, suggesting both potential benefits and adverse effects, but reports no new experimental results; the authors emphasize the need for more research to understand these pathways.

In this study, the researchers found that constitutive activation of the EGFR in mice led to increased sebum production, enlarged sebaceous glands, and altered gene expression related to sebocyte proliferation and lipogenesis.

This review suggests that imbalance in prostaglandin levels may contribute to androgenetic alopecia, highlighting prostaglandins as potential biomarkers and therapeutic targets for the condition.

This study found that adiponectin significantly enhanced lipid production in human sebaceous glands and may be a potential target for treating conditions with reduced sebum production.

This study confirmed that the novel solid lipid microparticle formulation of adapalene demonstrated follicular penetration potential and targeted particle erosion in sebum in in vitro tests.

In this study, researchers found that non-invasive analysis of skin surface lipid RNAs revealed alterations in gene expression patterns associated with atopic dermatitis, suggesting its potential for understanding skin disease pathophysiology.

This study found that skin surface lipids contain measurable mRNAs, providing a non-invasive way to study skin diseases, with specific gene expression changes observed in atopic dermatitis patients.

This study explored the structure and function of lipocalin prostaglandin D synthase, revealing its dual role in substrate catalysis and as a lipophilic ligand carrier, potentially informing future drug delivery design.

This review discusses the current research and development of mannosylerythritol lipids, particularly focusing on their potential commercial applications in cosmetics; it reports no new results.

This study found that patients with oral lichen planus and oral lichenoid reactions have higher levels of serum cholesterol and LDL-C than healthy individuals, suggesting a potential elevated risk for cardiovascular disease.

In this study, researchers observed that Malassezia species show different lipid metabolism and growth patterns depending on pH, with slightly acidic conditions promoting beneficial lipid bio-conversion for skin health, while neutral pH resulted in lower growth and lipid content, potentially negatively impacting the skin.

This study identified key lipid differences between black and white hair in individuals with premature greying, highlighting vitamin D3 as a potential target for further research in understanding this condition.

This study found that oral probiotic supplementation over 12 weeks may improve hair growth, skin condition, metabolic health, and stress responses in Chinese adults with hair loss and a high risk of metabolic syndrome.