Targeting Inflammation and Specialized Pro-Resolving Mediators to Reinforce Barrier Function and Scalp Homeostasis

November 2022 in “ Journal of Investigative Dermatology ”

Romain Duroux, Emeline VanGoethem, V. Baillif, Joan Attia

specialized pro-resolving lipid mediators SPMs scalp inflammation dandruff hair loss Anetholea anisita extract anti-inflammatory properties human follicle dermal papilla cells antioxidant effects Lipoxin B4 Resolvins D1 Resolvins D2 pro-inflammatory markers scalp barrier function hair brightness Anetholea anisita anti-inflammatory antioxidant Resolvins

TLDR Targeting inflammation can improve scalp and hair health.

The study investigates the role of specialized pro-resolving lipid mediators (SPMs) in scalp health, focusing on inflammation-related conditions like dandruff and hair loss. An extract of Anetholea anisita, known for its anti-inflammatory properties, was tested in vitro on human follicle dermal papilla cells and in vivo in a shampoo formula on 40 dandruff sufferers with oily hair over 28 days. The results showed that Anetholea anisita exhibited strong antioxidant and anti-inflammatory effects, increasing SPMs like Lipoxin B4 and Resolvins D1 and D2, while reducing pro-inflammatory markers. This led to improved scalp barrier function, reduced dandruff, and enhanced hair brightness, suggesting that targeting inflammation resolution is a promising strategy for improving scalp and hair health.

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