Targeting Inflammation and Specialized Pro-Resolving Mediators to Reinforce Barrier Function and Scalp Homeostasis

November 2022 in “ Journal of Investigative Dermatology ”

Romain Duroux, Emeline VanGoethem, V. Baillif, Joan Attia

specialized pro-resolving lipid mediators SPMs scalp inflammation dandruff hair loss Anetholea anisita extract anti-inflammatory properties human follicle dermal papilla cells antioxidant effects Lipoxin B4 Resolvins D1 Resolvins D2 pro-inflammatory markers scalp barrier function hair brightness Anetholea anisita anti-inflammatory antioxidant Resolvins

TLDR Targeting inflammation can improve scalp and hair health.

Specialized pro-resolving lipid mediators (SPMs) were studied for their role in resolving scalp inflammation, which is linked to conditions like dandruff and hair loss. Anetholea anisita extract, known for its anti-inflammatory properties, was tested in-vitro on human follicle dermal papilla cells and in a clinical trial with 40 dandruff sufferers. The extract showed strong antioxidant and anti-inflammatory effects, increased SPMs like Lipoxin B4 and Resolvins D1 and D2, and decreased pro-inflammatory markers. This led to improved scalp barrier function, reduced dandruff, and enhanced hair brightness, suggesting that targeting inflammation can improve scalp and hair health.

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