Integrative Proteo-Transcriptomic Characterization of Androgenetic Alopecia Identifying ME1-Mediated PPAR Signaling as a Potential Mediator

    December 2024 in “ Journal of Cosmetic Dermatology ”
    Ru Dai, Xiaoshuang Yang, Lixin Bao … Zhongfa Lu
    Studysummary In this study, researchers performed the first integrated transcriptomic and proteomic analysis of scalp biopsies from male androgenetic alopecia patients, finding a significant association between PPAR signaling pathways and AGA, with ME1 identified as a key regulator in this process.
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    Research cited in this study 8

    1. Application of Multi-Omics Techniques to Androgenetic Alopecia: Current Status and Perspectives Computational and Structural Biotechnology Journal · 2024
    2. Risk Factors and Lipid Metabolism Characteristics of Early-Onset Male Androgenetic Alopecia: A Pilot Study Journal of cosmetic dermatology · 2024
    3. Adipose Transcriptome in the Scalp of Androgenetic Alopecia Frontiers in Medicine · 2023
    4. Peroxisome Proliferator-Activated Receptor-γ Signalling Protects Hair Follicle Stem Cells from Chemotherapy-Induced Apoptosis and Epithelial-Mesenchymal Transition British journal of dermatology/British journal of dermatology, Supplement · 2021
    5. PPAR-γ Signaling as a Key Mediator of Human Hair Follicle Physiology and Pathology Experimental Dermatology · 2019
    6. Progressive Expression of PPARGC1α Is Associated with Hair Miniaturization in Androgenetic Alopecia Scientific Reports · 2019
    7. Adipose and Hair Function: An Apparent Connection Journal of Investigative Dermatology · 2018
    8. Peroxisome Proliferator-Activated Receptor-Gamma Mediated Signaling Regulates Mitochondrial Energy Metabolism in Human Hair Follicle Epithelium Journal of Investigative Dermatology · 2018