Metabolic and Transcriptomic Reprogramming During Contact Inhibition-Induced Quiescence Is Mediated by YAP-Dependent and YAP-Independent Mechanisms

    August 2024 in “ Nature Communications ”
    Soeun Kang, Maciek R. Antoniewicz, Nissim Hay
    Studysummary In this study, researchers observed that quiescent mouse embryonic fibroblasts showed reduced glycolysis but increased TCA cycle flux and mitochondrial respiration, with these changes linked to metabolic reprogramming involving yes-associated protein inhibition and malate cycle modulation, which supports extracellular matrix protein synthesis.
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    Research cited in this study 2

    1. Fibroblast State Switching Orchestrates Dermal Maturation and Wound Healing Molecular Systems Biology · 2018
    2. Inhibition of β-Catenin Signaling in Dermal Fibroblasts Enhances Hair Follicle Regeneration During Wound Healing Development · 2016