Anti-Allergic Effects of Fertilized Red Ginseng Marc on 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis-Like Mice Model

    February 2022 in “ Preprints.org ”
    Yeun Soo Jung, Jae Young Choi, Young-Sam Kwon, Gyu-Ryeul Park, VinayKumar Dachuri, Young Woo Kim, Sae‐Kwang Ku, Chang‐Hyun Song
    TLDR Fermented red ginseng marc may help treat atopic dermatitis by reducing inflammation and improving skin health.
    The study investigated the anti-allergic effects of fermented red ginseng marc (fRGM) on a 2,4-dinitrochlorobenzene-induced atopic dermatitis-like mice model. Over six weeks, mice were treated with distilled water (control), dexamethasone, or fRGM. The fRGM treatment alleviated skin lesions, reduced serum IgE levels, and decreased skin lipid peroxidation and superoxide anion levels while increasing glutathione content. It also down-regulated inflammatory mediator gene expressions and suppressed epidermal thickening, collagen deposition, and inflammatory cell infiltration. Additionally, fRGM reduced hypertrophic changes and inflammatory responses in the spleen and lymph node. While both dexamethasone and fRGM showed beneficial effects, antioxidant effects were unique to fRGM, suggesting its potential as a therapeutic source for atopic dermatitis.
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