Anti-Allergic Effects of Fertilized Red Ginseng Marc on 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis-Like Mice Model
February 2022
in “
Preprints.org
”
fermented red ginseng marc 2,4-dinitrochlorobenzene atopic dermatitis dexamethasone IgE glutathione inflammatory mediator gene expressions epidermal thickening collagen deposition inflammatory cell infiltration skin lipid peroxidation superoxide anion fRGM red ginseng steroid immune response antioxidant
Studysummary This study found that fermented red ginseng marc alleviated skin lesions, reduced inflammation, and demonstrated antioxidant effects in an AD-like mouse model, suggesting potential therapeutic applications for atopic dermatitis. Our plain-language summary of this paper — not a Tressless recommendation.
The study investigated the anti-allergic effects of fermented red ginseng marc (fRGM) on a 2,4-dinitrochlorobenzene-induced atopic dermatitis-like mice model. Over six weeks, mice were treated with distilled water (control), dexamethasone, or fRGM. The fRGM treatment alleviated skin lesions, reduced serum IgE levels, and decreased skin lipid peroxidation and superoxide anion levels while increasing glutathione content. It also down-regulated inflammatory mediator gene expressions and suppressed epidermal thickening, collagen deposition, and inflammatory cell infiltration. Additionally, fRGM reduced hypertrophic changes and inflammatory responses in the spleen and lymph node. While both dexamethasone and fRGM showed beneficial effects, antioxidant effects were unique to fRGM, suggesting its potential as a therapeutic source for atopic dermatitis.
