Influence of Bovine Milk Oligosaccharides on Sebocyte Lipid Content and Inflammatory Mediators

The study from May 2017 examined the impact of bovine milk-derived oligosaccharides (BMOs) on human sebocytes and found that BMOs significantly increased cell proliferation, intracellular lipid content, and the expression of the lipid synthesis transcription factor SREBP-1. The treatment with BMOs also altered mTOR signaling, decreasing mTORC2 activity by 28% while increasing mTORC1 activity by 57.4%. Additionally, BMOs significantly increased the expression of inflammatory mediators, with COX-2 and 5-LOX enzymes rising by 2.1-fold and 4-fold, respectively, and IL-6 expression in the supernatant of treated sebocytes increasing by 21-fold. These results suggest that BMOs could contribute to milk-based inflammation in sebocytes by promoting proliferation, lipid synthesis, and inflammation through the mTORC1 pathway.