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GlossaryCyclooxygenase-2

enzyme involved in inflammation and pain production

Cyclooxygenase-2 (COX-2) is an enzyme that plays a crucial role in the inflammatory process by converting arachidonic acid into prostaglandins, which are compounds that mediate inflammation and pain. Unlike its counterpart COX-1, which is expressed constantly in most tissues, COX-2 is typically induced during inflammation and is a target for anti-inflammatory drugs like NSAIDs (nonsteroidal anti-inflammatory drugs).

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Diphlorethohydroxycarmalol, Isolated from Ishige Okamurae, Increases Prostaglandin E2 through the Expression of Cyclooxygenase-1 and -2 in HaCaT Human Keratinocytes

research Diphlorethohydroxycarmalol, Isolated from Ishige Okamurae, Increases Prostaglandin E2 through the Expression of Cyclooxygenase-1 and -2 in HaCaT Human Keratinocytes

9 citations, November 2012 in “Biomolecules & therapeutics”

A compound from brown algae boosts the production of a certain inflammatory substance in skin cells.

Expression Pattern of Cyclooxygenase-2 in Normal Rat Epidermis and Pilosebaceous Unit During Hair Cycle

research Expression Pattern of Cyclooxygenase-2 in Normal Rat Epidermis and Pilosebaceous Unit During Hair Cycle

9 citations, January 2008 in “Acta histochemica et cytochemica”

COX-2 levels change during the hair cycle and affect skin and hair growth.

Overexpression of Cyclooxygenase-2 in the Skin of Adult Transgenic Mice Leads to Sebaceous Gland Hyperplasia and Thinning of Hair Shafts

research Overexpression of Cyclooxygenase-2 in the Skin of Adult Transgenic Mice Leads to Sebaceous Gland Hyperplasia and Thinning of Hair Shafts

April 2019 in “Journal of Investigative Dermatology”

Increasing COX-2 in mouse skin causes bigger sebaceous glands and thinner hair, but stopping COX-2 can reverse hair thinning.

Associations Between Variants in the Cyclooxygenase 2 Enzyme Gene (PTGS2) and Development of Benign Prostate Enlargement

research Associations Between Variants in the Cyclooxygenase 2 Enzyme Gene (PTGS2) and Development of Benign Prostate Enlargement

November 2012 in “The Journal of Urology”

Certain gene variants may raise the risk of prostate enlargement, but taking NSAIDs could reduce this risk.

Cutaneous Overexpression of Cyclooxygenase-2 Models Androgenetic Alopecia in Adult Mice

research Cutaneous Overexpression of Cyclooxygenase-2 Models Androgenetic Alopecia in Adult Mice

April 2021 in “Journal of Investigative Dermatology”

Cyclooxygenase-2 overexpression in mice skin causes hair loss like human androgenetic alopecia.

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