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GlossaryCyclooxygenase-1

enzyme involved in producing compounds that regulate inflammation and protect stomach lining

Cyclooxygenase-1 (COX-1) is an enzyme that plays a crucial role in the production of prostaglandins, which are lipid compounds that perform various functions in the body, such as regulating inflammation, protecting the stomach lining, and maintaining kidney function. Unlike its counterpart COX-2, which is typically induced during inflammation, COX-1 is constitutively expressed, meaning it is produced continuously in most tissues to maintain normal physiological processes.

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Diphlorethohydroxycarmalol, Isolated from Ishige Okamurae, Increases Prostaglandin E2 through the Expression of Cyclooxygenase-1 and -2 in HaCaT Human Keratinocytes

research Diphlorethohydroxycarmalol, Isolated from Ishige Okamurae, Increases Prostaglandin E2 through the Expression of Cyclooxygenase-1 and -2 in HaCaT Human Keratinocytes

9 citations , November 2012 in “Biomolecules & therapeutics”

A compound from brown algae boosts the production of a certain inflammatory substance in skin cells.

research Mimosine Dipeptide Enantiomers: Improved Inhibitors Against Melanogenesis And Cyclooxygenase

25 citations , August 2015 in “Molecules”

Mimosine dipeptides are promising for treating hyperpigmentation and inflammation.

research Cyclooxygenases in the Skin: Pharmacological and Toxicological Implications

165 citations , September 2003 in “Toxicology and applied pharmacology”

Blocking COX, especially COX-2, in the skin can reduce inflammation and pain and may help prevent skin cancer.

research Autotaxin–Lysophosphatidic Acid–LPA3 Signaling at the Embryo-Epithelial Boundary Controls Decidualization Pathways

44 citations , June 2017 in “The EMBO Journal”

LPA3 signaling in the uterus is crucial for placental formation and fetal development.

research Expression of Cyclooxygenase Isozymes During Morphogenesis and Cycling of Pelage Hair Follicles in Mouse Skin: Precocious Onset of the First Catagen Phase and Alopecia Upon Cyclooxygenase-2 Overexpression

41 citations , September 2003 in “Journal of Investigative Dermatology”

Overexpression of COX-2 causes early hair loss in mice, but can be prevented with a COX-2 inhibitor.

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community Painkillers May Block Minoxidil

in Research/Science 14 upvotes 11 months ago

Painkillers like Aspirin may reduce Minoxidil's effectiveness by inhibiting the enzyme PGHS-1, which is crucial for hair growth. Using NSAIDs that inhibit COX-2 or combining Minoxidil with PGF2/E2 analogues or retinoids may enhance its efficacy.

community Brotzu lotion update

in Update 90 upvotes 8 years ago

A new hair loss lotion by Dr. Brotzu, expected to regrow up to 5 years of lost hair, is set to be released by Fidia Farmaceutici. It claims to work like minoxidil and finasteride without side effects, but skepticism exists due to its classification as a cosmetic product.