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GlossaryCyclooxygenase-1

enzyme involved in producing compounds that regulate inflammation and protect stomach lining

Cyclooxygenase-1 (COX-1) is an enzyme that plays a crucial role in the production of prostaglandins, which are lipid compounds that perform various functions in the body, such as regulating inflammation, protecting the stomach lining, and maintaining kidney function. Unlike its counterpart COX-2, which is typically induced during inflammation, COX-1 is constitutively expressed, meaning it is produced continuously in most tissues to maintain normal physiological processes.

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Diphlorethohydroxycarmalol, Isolated from Ishige Okamurae, Increases Prostaglandin E2 through the Expression of Cyclooxygenase-1 and -2 in HaCaT Human Keratinocytes

research Diphlorethohydroxycarmalol, Isolated from Ishige Okamurae, Increases Prostaglandin E2 through the Expression of Cyclooxygenase-1 and -2 in HaCaT Human Keratinocytes

9 citations, November 2012 in “Biomolecules & therapeutics”

A compound from brown algae boosts the production of a certain inflammatory substance in skin cells.

research Wound Healing Impairment in Type 2 Diabetes Model of Leptin-Deficient Mice: A Mechanistic Systematic Review

10 citations, August 2022 in “International Journal of Molecular Sciences”

Leptin-deficient mice, used as a model for Type 2 Diabetes, have delayed wound healing due to impaired contraction and other dysfunctional cellular responses.

research A New Target for Squamous Cell Skin Cancer?

6 citations, October 2014 in “Experimental Dermatology”

Prostaglandins and the enzyme AKR1C3 could play a role in skin cancer and hair loss, and further research is needed to understand these mechanisms.

research Autotaxin–Lysophosphatidic Acid–LPA3 Signaling at the Embryo-Epithelial Boundary Controls Decidualization Pathways

44 citations, June 2017 in “The EMBO Journal”

LPA3 signaling in the uterus is crucial for placental formation and fetal development.

research Cyclooxygenases in the Skin: Pharmacological and Toxicological Implications

165 citations, September 2003 in “Toxicology and applied pharmacology”

Blocking COX, especially COX-2, in the skin can reduce inflammation and pain and may help prevent skin cancer.

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