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    Glossary Cyclooxygenase-1

    enzyme involved in producing compounds that regulate inflammation and protect stomach lining

    Cyclooxygenase-1 (COX-1) is an enzyme that plays a crucial role in the production of prostaglandins, which are lipid compounds that perform various functions in the body, such as regulating inflammation, protecting the stomach lining, and maintaining kidney function. Unlike its counterpart COX-2, which is typically induced during inflammation, COX-1 is constitutively expressed, meaning it is produced continuously in most tissues to maintain normal physiological processes.

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    Research 30 of 666

    1. Diphlorethohydroxycarmalol, Isolated from Ishige okamurae, Increases Prostaglandin E<sub>2</sub>through the Expression of Cyclooxygenase-1 and -2 in HaCaT Human Keratinocytes Biomolecules & therapeutics · 2012 · 9 citations
    2. Mimosine Dipeptide Enantiomsers: Improved Inhibitors against Melanogenesis and Cyclooxygenase Molecules · 2015 · 25 citations
    3. Anti-inflammatory, cyclooxygenase inhibitory and antioxidant activities of standardized extracts of Tridax procumbens L. Fitoterapia · 2010 · 61 citations
    4. Cepharanthine: A review of the antiviral potential of a Japanese-approved alopecia drug in COVID-19 2020 · 4 citations
    5. Wound Healing Impairment in Type 2 Diabetes Model of Leptin-Deficient Mice—A Mechanistic Systematic Review International Journal of Molecular Sciences · 2022 · 10 citations
    6. A new target for squamous cell skin cancer? Experimental Dermatology · 2014 · 6 citations
    7. 878 Influence of bovine milk oligosaccharides on sebocyte lipid content and inflammatory mediators Journal of Investigative Dermatology · 2017
    8. Functional Characterization of Callus Extracts of Apple 'Hirosaki' for Cosmetic Materials 2013
    9. Molecular mechanisms underlying cashmere quality differences between Jiangnan cashmere goats and Changthangi pashmina goats Frontiers in Veterinary Science · 2025
    10. Clinical Snippets Journal of Investigative Dermatology · 2003 · 1 citations
    11. Cyclooxygenase-2 overexpression in the skin of transgenic mice results in suppression of tumor development. PubMed · 2002 · 113 citations
    12. Abnormal differentiation of epidermis in transgenic mice constitutively expressing cyclooxygenase-2 in skin Proceedings of the National Academy of Sciences · 2001 · 201 citations
    13. Re: Associations Between Variants in the Cyclooxygenase 2 Enzyme Gene (PTGS2) and Development of Benign Prostate Enlargement The Journal of Urology · 2012
    14. Improvement of cell proliferation and antioxidant activity of silymarin in hair follicles dermal papillae isolated from the human scalp: Comparison with vitamin C effects International Journal of Trichology · 2020 · 8 citations
    15. Liquid Chromatography-Mass Spectrometry-Based In Vitro Metabolic Profiling Reveals Altered Enzyme Expressions in Eicosanoid Metabolism Annals of laboratory medicine · 2016
    16. Autotaxin–lysophosphatidic acid– LPA <sub>3</sub> signaling at the embryo‐epithelial boundary controls decidualization pathways The EMBO Journal · 2017 · 44 citations
    17. Metabolic pathways of eicosanoids—derivatives of arachidonic acid and their significance in skin Cellular & Molecular Biology Letters · 2025
    18. Expression of Cyclooxygenase Isozymes During Morphogenesis and Cycling of Pelage Hair Follicles in Mouse Skin: Precocious Onset of the First Catagen Phase and Alopecia upon Cyclooxygenase-2 Overexpression Journal of Investigative Dermatology · 2003 · 41 citations
    19. Expression Pattern of Cyclooxygenase-2 in Normal Rat Epidermis and Pilosebaceous Unit during Hair Cycle Acta histochemica et cytochemica · 2008 · 9 citations
    20. Cyclooxygenases in the skin: pharmacological and toxicological implications Toxicology and applied pharmacology · 2003 · 165 citations
    21. Protein Kinase C δ Overexpressing Transgenic Mice Are Resistant to Chemically but not to UV Radiation–Induced Development of Squamous Cell Carcinomas: A Possible Link to Specific Cytokines and Cyclooxygenase-2 Cancer Research · 2006 · 35 citations
    22. Anti-inflammatory effects on murine macrophages of ethanol extracts of Lygodium japonicum spores via inhibition of NF-κB and p38 Molecular Medicine Reports · 2017 · 5 citations
    23. Novel Clove Essential Oil Nanoemulgel Tailored by Taguchi’s Model and Scaffold-Based Nanofibers: Phytopharmaceuticals with Promising Potential as Cyclooxygenase-2 Inhibitors in External Inflammation International Journal of Nanomedicine · 2020 · 45 citations
    24. UV light may induce hypertrichosis through production of PGE2 Medical hypotheses · 2006 · 7 citations
    25. 919 Overexpression of cyclooxygenase-2 in the skin of adult transgenic mice leads to sebaceous gland hyperplasia and thinning of hair shafts Journal of Investigative Dermatology · 2019
    26. 607 Cutaneous overexpression of cyclooxygenase-2 models androgenetic alopecia in adult mice Journal of Investigative Dermatology · 2021
    27. Enzymes British Journal of Pharmacology · 2008
    28. Prostate cancer prevention Cancer · 2007 · 71 citations
    29. New insights into the functions of Cox-2 in skin and esophageal malignancies Experimental & Molecular Medicine · 2020 · 54 citations
    30. Eupafolin nanoparticles protect HaCaT keratinocytes from particulate matter-induced inflammation and oxidative stress International Journal of Nanomedicine · 2016 · 43 citations