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    Glossary Lipid Accumulation

    excessive fat build-up within cells or tissues

    Lipid accumulation, also known as fat accumulation, refers to the build-up of lipids (fats) within cells or tissues. This process can occur in various parts of the body, including the liver, muscles, and skin, and is often associated with metabolic disorders such as obesity, diabetes, and cardiovascular diseases. In the context of hair and alopecia, excessive lipid accumulation in the scalp can potentially disrupt normal hair follicle function, contributing to hair loss.

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    1. Association between Lipid Accumulation Product and Hirsutism in Patients with Polycystic Ovary Syndrome Revista Brasileira de Ginecologia e Obstetrícia · 2016 · 1 citations
    2. 1329 Transglutaminase 2 deficiency leads to lipid accumulation and reduced autophagy in SZ95 sebocytes 2023
    3. Cedrol mitigates hepatic lipid accumulation and adipocyte hypertrophy induced by corticosteroids through the inhibition of glucocorticoid receptor activity Scientific Reports · 2025
    4. Real-time iTRAQ-based proteome profiling revealed the central metabolism involved in nitrogen starvation induced lipid accumulation in microalgae Scientific Reports · 2017 · 73 citations
    5. 696 MEK and BRAF inhibitors augment the production and accumulation of sebum in hamster sebocytes Journal of Investigative Dermatology · 2016
    6. Maternal PPARγ protects nursing neonates by suppressing the production of inflammatory milk Genes & Development · 2007 · 102 citations
    7. Syndecan-1 Is Required to Maintain Intradermal Fat and Prevent Cold Stress PLOS genetics · 2014 · 88 citations
    8. Comparative studies of the ultrastructure of the sebaceous gland Tissue and Cell · 1985 · 40 citations
    9. Alkaline Ceramidase 1 Protects Mice from Premature Hair Loss by Maintaining the Homeostasis of Hair Follicle Stem Cells Stem Cell Reports · 2017 · 20 citations
    10. Elevated fasting insulin is associated with cardiovascular and metabolic risk in women with polycystic ovary syndrome Diabetes and Metabolic Syndrome: Clinical Research and Reviews · 2019 · 17 citations
    11. Association between Insulin Resistance and Cardiovascular Risk Factors in Polycystic Ovary Syndrome Patients Revista Brasileira de Ginecologia e Obstetrícia · 2018 · 15 citations
    12. Exosomes Derived From Human Adipose-Derived Stem Cells Inhibit Lipogenesis Involving Hedgehog Signaling Pathway Frontiers in Bioengineering and Biotechnology · 2021 · 13 citations
    13. Comparative characterization and osteogenic / adipogenic differentiation of mesenchymal stem cells derived from male rat hair follicles and bone marrow Cell regeneration · 2020 · 6 citations
    14. Parameters of obesity in polycystic ovary syndrome Journal of rare disease research & treatment · 2017 · 1 citations
    15. Integrated evaluation of umbilical cord mesenchymal stromal cell-derived extracellular vesicles across skin-related cellular and zebrafish models Frontiers in Bioengineering and Biotechnology · 2026
    16. 110 Transglutaminase 2 is a potential regulator of sebocyte maturation 2017
    17. Unravelling the link between insulin resistance and androgen excess University of Birmingham Institutional Research Archive (University of Birmingham) · 2015
    18. Clinical Usefulness of Non-Invasive Metabolic-Associated Fatty Liver Disease Risk Assessment Methods in Patients with Full-Blown Polycystic Ovary Syndrome in Relation to the MRI Examination with the Ideal IQ Sequence Biomedicines · 2022
    19. Rodent models in placental research. Implications for fetal origins of adult disease Animal Reproduction · 2022 · 7 citations
    20. Health Risks Associated with Long-Term Finasteride and Dutasteride Use: It’s Time to Sound the Alarm The World Journal of Men's Health · 2020 · 17 citations
    21. Investigation of the cutaneous penetration behavior of dexamethasone loaded to nano-sized lipid particles by EPR spectroscopy, and confocal Raman and laser scanning microscopy European journal of pharmaceutics and biopharmaceutics · 2016 · 21 citations
    22. Dutasteride-loaded nanostructured lipid carrier for androgenic alopecia treatment - An <i>in vivo</i> study. PubMed · 2026
    23. Squarticles as a Lipid Nanocarrier for Delivering Diphencyprone and Minoxidil to Hair Follicles and Human Dermal Papilla Cells Aaps Journal · 2013 · 62 citations
    24. The impact of particle size of nanostructured lipid carriers on follicular drug delivery: A comprehensive analysis of mouse and human hair follicle penetration Bioimpacts · 2024
    25. Podophyllotoxin-loaded solid lipid nanoparticles for epidermal targeting Journal of controlled release · 2005 · 297 citations
    26. In Vitro Evaluation of Topical Follicular Delivery of Minoxidil and Latanoprost Co-Entrapped in Lipid Nanocarriers 2026
    27. Dihydroartemisinin loaded nanostructured lipid carriers (DHA-NLC): evaluation of pharmacokinetics and tissue distribution after intravenous administration to rats. PubMed · 2010 · 11 citations
    28. Inhibition of autophagy-lysosomal function exacerbates microglial and monocyte lipid metabolism reprograming and dysfunction after brain injury 2025
    29. Marine Health-Promoting Compounds: Recent Trends for Their Characterization and Human Applications Foods · 2021 · 18 citations
    30. Effects of α-Synuclein on the Lipid Phenotype of SZ95 Human Sebocytes: A Preliminary Study in the Context of Parkinson’s Disease Cells · 2026