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    Glossary Keratin 15

    protein crucial for hair follicle stem cell regulation

    Keratin 15 (K15) is a type of protein found in the hair follicles and skin, playing a crucial role in the structural integrity and function of these tissues. It is particularly important for the maintenance and regeneration of hair, as it is involved in the regulation of stem cells within the hair follicle, which are essential for hair growth and repair.

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    1. Keratin K15 as a Biomarker of Epidermal Stem Cells International Journal of Molecular Sciences · 2013 · 85 citations
    2. Two Mechanisms Regulate Keratin K15 Expression In Keratinocytes: Role of PKC/AP-1 and FOXM1 Mediated Signalling PloS one · 2012 · 35 citations
    3. Expression of the Intermediate Filament Keratin Gene,K15,in the Basal Cell Layers of Epithelia and the Hair Follicle Experimental Cell Research · 1998 · 46 citations
    4. Abstract 5022: Keratin15 (Krt15) + are radio resistant and tumor-initiating cells in the mouse small intestine Cancer Research · 2017
    5. Prolactin—a novel neuroendocrine regulator of human keratin expression<i>in situ</i> The FASEB Journal · 2010 · 64 citations
    6. Expression of the hair stem cell-specific keratin 15 in pilar tumors of the skin. PubMed · 1999 · 54 citations
    7. Keratin 15 promotes a progenitor cell state in basal keratinocytes of skin epidermis The Journal of Cell Biology · 2025
    8. An Investigation of Keratin 15 Function by Small Interfering Ribonucleic Acid Technology Durham e-Theses (Durham University) · 2012
    9. K15 & Id3 expression in intact and regenerating adult vibrissae rodent hair follicles 2009
    10. Vibrissa hair bulge houses two populations of skin epithelial stem cells distinct by their keratin profile ˜The œFASEB journal · 2007 · 45 citations
    11. Equine Hoof Stem Progenitor Cells (HPC) CD29 + /Nestin + /K15 + – a Novel Dermal/epidermal Stem Cell Population With a Potential Critical Role for Laminitis Treatment Stem Cell Reviews and Reports · 2021 · 6 citations
    12. N1-methylspermidine, a stable spermidine analog, prolongs anagen and regulates epithelial stem cell functions in human hair follicles Archives of dermatological research · 2015 · 13 citations
    13. Keratin 15 Promoter Targets Putative Epithelial Stem Cells in the Hair Follicle Bulge Journal of Investigative Dermatology · 2003 · 387 citations
    14. Spermidine Promotes Human Hair Growth and Is a Novel Modulator of Human Epithelial Stem Cell Functions PLOS ONE · 2011 · 61 citations
    15. Advanced Inhibition of Undesired Human Hair Growth by PPARγ Modulation? 2013 · 28 citations
    16. Human epithelial hair follicle stem cells and their progeny: Current state of knowledge, the widening gap in translational research and future challenges BioEssays · 2014 · 106 citations
    17. Disruption of Smad4 in Mouse Epidermis Leads to Depletion of Follicle Stem Cells Molecular biology of the cell · 2008 · 43 citations
    18. Isolating Hair Follicle Stem Cells and Epidermal Keratinocytes from Dorsal Mouse Skin Journal of Visualized Experiments · 2016 · 23 citations
    19. The contribution of stem cells to epidermal and hair follicle tumours in the dog Veterinary Dermatology · 2013 · 18 citations
    20. Isolation of Stem Cells and Progenitors from Mouse Epidermis Current Protocols in Stem Cell Biology · 2017 · 13 citations
    21. Sebaceous Gland Regeneration in Human Skin Xenografts Journal of Investigative Dermatology · 2010 · 9 citations
    22. Hair follicle stem cell marker nestin expression in regenerating hair follicles of patients with alopecia areata European Journal of Dermatology · 2011 · 6 citations
    23. Nestin is a marker of unipotent embryonic and adult progenitors differentiating into an epithelial cell lineage of the hair follicles Scientific reports · 2022 · 1 citations
    24. LB965 Follicular trochanters: A potential mechanism for stem cell depletion in scarring alopecia 2020
    25. Isolating Hair Follicle Stem Cells and Epidermal Keratinocytes from Dorsal Mouse Skin Journal of Visualized Experiments · 2016 · 13 citations
    26. Lineage Tracing of Hair Follicle Stem Cells in Epidermal Whole Mounts Methods in molecular biology · 2013 · 11 citations
    27. Inhibitory effect of 7DHC and BM15766 in HF organoid culture. OPAL (Open@LaTrobe) (La Trobe University) · 2025
    28. Nestin as a marker of unipotent epithelial progenitor cells differentiate into outer root sheath keratinocytes in embryonic and adult hair follicles Research Square (Research Square) · 2022
    29. Milia may originate from the outermost layers of the hair bulge of the outer root sheath: A case report Oncology Letters · 2016
    30. Faculty Opinions recommendation of Competitive balance of intrabulge BMP/Wnt signaling reveals a robust gene network ruling stem cell homeostasis and cyclic activation. Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2013