Epidermal Retinol Dehydrogenases Cyclically Regulate Stem Cell Markers and Clock Genes and Influence Hair Composition

    April 2024 in “ Communications biology ”
    Kelli R. Goggans, Olga V. Belyaeva, Alla Klyuyeva … Natalia Y. Kedishvili
    Studysummary The researchers reported that disrupting ATRA signaling by deleting RDHE genes in the hair follicle led to altered hair follicle cycles, composition, and gene expression, indicating RDHEs' role in hair follicle signaling coordination.
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    Research cited in this study 23

    1. Vitamin A in Skin and Hair: An Update Nutrients · 2022
    2. Estrogen Regulates the Expression of Retinoic Acid Synthesis Enzymes and Binding Proteins in Mouse Skin Nutrition research · 2021
    3. Dietary Vitamin A Impacts Refractory Telogen Frontiers in Cell and Developmental Biology · 2021
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    5. Keratin K15 as a Biomarker of Epidermal Stem Cells International Journal of Molecular Sciences · 2013
    6. Retinoid Metabolism Is Altered in Human and Mouse Cicatricial Alopecia Journal of Investigative Dermatology · 2012
    7. Endogenous Retinoids in the Pathogenesis of Alopecia Areata ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2012
    8. Cutaneous Retinoic Acid Levels Determine Hair Follicle Development And Downgrowth Journal of biological chemistry/˜The œJournal of biological chemistry · 2012
    9. Estrogen Leads to Reversible Hair Cycle Retardation Through Inducing Premature Catagen and Maintaining Telogen PLOS ONE · 2012
    10. New Activators and Inhibitors in the Hair Cycle Clock: Targeting Stem Cells’ State of Competence Journal of Investigative Dermatology · 2012
    11. Self-Organizing and Stochastic Behaviors During the Regeneration of Hair Stem Cells Science · 2011
    12. Beta-Catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair Developmental Cell · 2010
    13. Epidermal Patterning and Induction of Different Hair Types During Mouse Embryonic Development Birth defects research · 2009
    14. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    15. Retinol Esterification by DGAT1 Is Essential for Retinoid Homeostasis in Murine Skin Journal of biological chemistry/˜The œJournal of biological chemistry · 2008
    16. Lgr5 Marks Cycling, Yet Long-Lived, Hair Follicle Stem Cells Nature Genetics · 2008
    17. Immunolocalization of Enzymes, Binding Proteins, and Receptors Sufficient for Retinoic Acid Synthesis and Signaling During the Hair Cycle ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2007
    18. Scratching the Surface of Skin Development Nature · 2007
    19. Towards Dissecting the Pathogenesis of Retinoid-Induced Hair Loss: All-Trans Retinoic Acid Induces Premature Hair Follicle Regression by Upregulation of Transforming Growth Factor-β2 in the Dermal Papilla Journal of Investigative Dermatology · 2005
    20. Keratin 15 Promoter Targets Putative Epithelial Stem Cells in the Hair Follicle Bulge Journal of Investigative Dermatology · 2003
    21. Enrichment for Living Murine Keratinocytes from the Hair Follicle Bulge with the Cell Surface Marker CD34 Journal of Investigative Dermatology · 2003
    22. Novel Cycle Changes in Scalp Hair Are Caused by Etretinate Therapy British Journal of Dermatology · 1995
    23. Effect of Retinoids on Follicular Cells ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1993

    Related research 6

    1. Morphogenesis, Growth Cycle, and Molecular Regulation of Hair Follicles Frontiers in Cell and Developmental Biology · 2022
    2. Dermal Papilla-Derived Wnt Ligands Are Required for Adult Hair Follicle Growth Journal of Investigative Dermatology · 2016
    3. Putting the Human Hair Follicle Cycle on the Map Journal of Investigative Dermatology · 2016
    4. Hair Cycle Resting Phase Is Regulated by Cyclic Epithelial FGF18 Signaling Journal of Investigative Dermatology · 2012
    5. Biology of the Hair Follicle: The Basics Seminars in Cutaneous Medicine and Surgery · 2006
    6. Expression of E6 and E7 Papillomavirus Oncogenes in the Outer Root Sheath of Hair Follicles Extends the Growth Phase and Bypasses Resting at Telogen PubMed · 2000