14 citations
,
January 2018 in “Endocrinology and Metabolism” This study found that older age and obesity are predictors of metabolic syndrome and insulin resistance syndrome among infertile Vietnamese women with PCOS.
16 citations
,
January 2012 in “European Journal of Endocrinology” This study reports an increased frequency of the DI genotype of the ACE gene polymorphism among women with PCOS, notably in those with hyperandrogenism, and an association of the II genotype with insulin resistance.
6 citations
,
April 2016 in “Journal of the Formosan Medical Association” This study found that metformin treatment improved clinical outcomes in Taiwanese women with polycystic ovary syndrome, notably in overweight and insulin-resistant patients.
5 citations
,
September 2021 in “Cureus” This paper explores the mechanisms causing depression in women with PCOS and suggests that lifestyle modifications, such as dietary changes and weight loss, as well as cognitive behavioral therapy and antidepressants, can help manage PCOS-induced depression.
November 2025 in “Cureus” This review discusses the link between PCOS and acne, highlighting the roles of hyperandrogenism and insulin resistance, but it reports no new clinical findings.
June 2021 in “International Journal of Research in Dermatology” This study found that one-third of females with acne and PCOS also showed insulin resistance, suggesting that women with these conditions should be evaluated for impaired glucose tolerance.
November 2004 in “John Wiley & Sons, Ltd eBooks” This chapter reviews polycystic ovary syndrome (PCOS), focusing on its definition, causes, and treatment approaches, but reports no new research findings.
29 citations
,
January 2011 in “Journal of Obstetrics and Gynaecology” This review discusses insulin resistance in women with polycystic ovary syndrome and reports no new clinical results; it highlights the potential benefits of lifestyle changes and insulin-sensitizing drugs.
11 citations
,
January 2012 in “International Journal of Endocrinology” In this study, the prevalence of insulin resistance in reproductive-aged Thai women with polycystic ovary syndrome was found to be 20%, with age, waist circumference, acanthosis nigricans, and dyslipidemia as significant predictors.
4 citations
,
November 2016 in “Archives of Endocrinology and Metabolism” This study found that thyroid volume was increased in PCOS patients with insulin resistance, with potential influences from TSH and LH levels on these changes.
This review examines the development, pathogenesis, and effects of insulin resistance, highlighting its connections to numerous health conditions, without presenting new research findings.
33 citations
,
September 2014 in “Reproductive Biology and Endocrinology” In this study, elevated afamin concentrations were associated with metabolic syndrome in young women, particularly those with insulin resistance, suggesting a potential predictive role for afamin in metabolic risk assessment.
26 citations
,
June 2014 in “Fertility and Sterility” In this study, normal weight adolescents with PCOS showed increased insulin resistance and significantly lower levels of high molecular weight adiponectin compared to controls, despite no other metabolic differences.
19 citations
,
March 2007 in “Journal of diabetes science and technology” This study found that both metformin and rosiglitazone improved ovulation and insulin sensitivity in women with PCOS, with rosiglitazone showing a more pronounced increase in adiponectin levels.
12 citations
,
January 2016 in “Journal of Assisted Reproduction and Genetics” This study suggests that genetic variations in the AMH signal pathway may be linked to susceptibility and phenotype variations in PCOS among women with insulin resistance.
7 citations
,
December 2014 in “Australasian journal of dermatology” In this study, insulin resistance was observed at similar rates in non-obese women with idiopathic hirsutism, those with PCOS, and healthy controls.
4 citations
,
September 2013 in “Expert Review of Endocrinology & Metabolism” Different types of polycystic ovary syndrome show varying levels of insulin resistance, with the 'PHO' type being the most insulin resistant.
3 citations
,
April 2019 in “Hormone and Metabolic Research” This study found that women with polycystic ovary syndrome have higher insulin resistance and lower serum high-molecular weight adiponectin, which may play a role in the condition's pathogenesis.
3 citations
,
August 2015 in “Diabetes and Metabolic Syndrome: Clinical Research and Reviews” This study suggests that type 2 diabetes mellitus and polycystic ovary syndrome are separate medical entities despite both being linked to insulin resistance.
2 citations
,
July 2024 in “Ibn AL- Haitham Journal For Pure and Applied Science” This study found that PCOS women with COVID-19 had lower ACE2 levels and higher insulin resistance, suggesting increased cardiovascular risk.
1 citations
,
November 2023 in “Reproductive biology and endocrinology” This study found that among Iranian women with PCOS, phenotype B displayed the highest prevalence of insulin resistance, significantly differing from other phenotypes, suggesting phenotype could guide management of PCOS-related insulin issues.
October 2025 in “Indian Journal of Physiology and Pharmacology” This case study suggests a potential connection between insulin resistance-induced diabetes and the development of migraine symptoms in a patient with HAIR-AN syndrome, highlighting the importance of early diagnosis and a multifaceted treatment approach.
January 2016 in “International Journal of Reproduction Contraception Obstetrics and Gynecology” This study found that insulin resistance varies across different PCOS phenotypes, with the PCOM+MI+HA phenotype showing higher resistance than others.
January 2015 in “International Journal of Research in Medical Sciences” This case report is the first to associate HAIR-AN syndrome with polycystic ovaries, Hashimoto’s thyroiditis, and several metabolic conditions in a 21-year-old woman, emphasizing early diagnosis and management.
270 citations
,
April 2007 in “The Journal of Clinical Endocrinology and Metabolism” This study found that PCOS patients had higher amounts of central abdominal fat compared to weight-matched controls, which was associated with increased insulin resistance.
222 citations
,
January 2014 in “International journal of reproductive medicine” This paper reviews the complex pathophysiology of polycystic ovary syndrome, exploring how hormonal and metabolic disturbances contribute to its symptoms and related health risks, but it presents no new findings.
195 citations
,
November 2019 in “Clinica Chimica Acta” This review discusses the interplay of hyperandrogenism, insulin resistance, obesity, and their role in polycystic ovary syndrome, but presents no new clinical results.
100 citations
,
June 2002 in “Diabetologia” This study found that parents of women with PCOS have a higher prevalence of insulin resistance and Type II diabetes than parents of healthy women.
91 citations
,
November 2007 in “European journal of endocrinology” This study found that metformin improved insulin resistance, hyperandrogenemia, anovulation, and acne in PCOS patients, regardless of their level of obesity or initial insulin resistance.
62 citations
,
December 2015 in “Clinical Medicine” This review discusses the relationship between obesity and PCOS, highlighting the potential of weight loss and improved insulin sensitivity to alleviate associated symptoms, and suggests the exploration of new therapies targeting weight management.