Afamin Serum Concentrations Are Associated With Insulin Resistance and Metabolic Syndrome in Polycystic Ovary Syndrome

    September 2014 in “ Reproductive Biology and Endocrinology ”
    Beata Seeber, Elisabeth Morandell, Fabian Lunger, L. Wildt, Hans Dieplinger
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    TLDR High afamin levels are linked to metabolic syndrome and may predict its development in women with insulin resistance.
    In the 2014 study by Seeber et al., researchers examined the link between afamin serum concentrations and insulin resistance (IR) as well as metabolic syndrome (MetS) in 53 women with polycystic ovary syndrome (PCOS) and 49 controls. They found no significant difference in afamin levels between the overall PCOS and control groups. However, PCOS patients with IR had significantly higher afamin levels than those without IR. Additionally, afamin concentrations were significantly higher in subjects with MetS. Triglyceride levels were identified as the only independent predictor of afamin concentrations. The study concluded that high afamin concentrations are associated with MetS and could be an independent predictor for its development in women at risk, particularly those with IR.
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