Prevalence of Type II Diabetes Mellitus and Insulin Resistance in Parents of Women with Polycystic Ovary Syndrome

June 2002 in “ Diabetologia ”

Teresa Sir‐Petermann, Bárbara Ángel, Manuel Maliqueo, Francisca Carvajal, José Luis Santos, F. Pérez-Bravo

Type II diabetes mellitus insulin resistance polycystic ovary syndrome PCOS male-pattern balding genetic susceptibility Type 2 diabetes male-pattern baldness

TLDR Parents of women with PCOS have a higher risk of Type II diabetes and insulin resistance, especially fathers.

The study investigated the prevalence of Type II diabetes mellitus and insulin resistance in parents of women with polycystic ovary syndrome (PCOS) compared to parents of healthy women, involving 200 parents of women with PCOS and 120 parents of healthy women. It found that the prevalence of Type II diabetes was 1.89 times higher in parents of women with PCOS, with significantly higher insulin resistance in this group. Fathers of PCOS women showed more metabolic abnormalities than mothers, suggesting a potential paternal genetic component. The study highlighted the importance of targeted screening and prevention strategies for this high-risk group and noted a possible link between PCOS and premature male-pattern balding in male relatives, indicating a shared genetic susceptibility.

View this study on link.springer.com →

Discuss this study in the Community →

Research cited in this study

5 / 5 results

research Early Androgenetic Alopecia as a Marker of Insulin Resistance

115 citations , September 2000 in “The Lancet”

Early hair loss may indicate risk of insulin resistance.

research Polycystic Ovaries Are Inherited as an Autosomal Dominant Trait: Analysis of 29 Polycystic Ovary Syndrome and 10 Control Families

63 citations , January 1999 in “The Journal of Clinical Endocrinology & Metabolism”

Polycystic ovaries and early male baldness are inherited traits.

research Prevalence of Polycystic Ovary Syndrome in Unselected Black and White Women of the Southeastern United States: A Prospective Study

633 citations , September 1998 in “The Journal of Clinical Endocrinology and Metabolism”

PCOS affects a similar percentage of Black and White women in the Southeastern United States.

research Prevalence of Polycystic Ovary Syndrome in Unselected Black and White Women of the Southeastern United States: A Prospective Study

378 citations , September 1998 in “The Journal of Clinical Endocrinology and Metabolism”

PCOS affects about 4% of women in the southeastern U.S. equally across Black and White populations.

research Polycystic Ovary Syndrome: Clinical and Biochemical Features

1947 citations , September 1995 in “New England journal of medicine/The New England journal of medicine”

PCOS is a common hormonal disorder causing irregular periods and increased hair growth, linked to insulin resistance and long-term health issues.

Related Community Posts Join

6 / 1000+ results

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community What treatment helps diffuse hair thinning from insulin resistance?

in Treatment 1 upvotes 2 years ago

The individual is experiencing hair loss due to insulin resistance (IR) and is seeking advice. They are currently using a keto diet, supplements, exercise, and plan to add metformin to their regimen.

community Interesting article links major MPB theories to western diet (and life-style)

in Research/Science 58 upvotes 1 year ago

Poor diet and lifestyle contribute to male pattern baldness. Treatments like Minoxidil, dietary changes, and lifestyle adjustments may help slow hair loss.

community Why do we have head hair in first place if we evolved to start losing it in some cases as soon as puberty hits

in Chat 138 upvotes 5 months ago

Hair loss is influenced by genetics and sensitivity to hormones like DHT. Treatments like Minoxidil and finasteride are commonly used, and baldness persists as it doesn't affect reproductive success.

community Is finasteride enough for diffuse thinning without recession?

in Finasteride/Dutasteride 19 upvotes 10 months ago

Finasteride may be sufficient for diffuse thinning, but dutasteride is generally considered more effective, with a higher chance of hair growth. Adding oral minoxidil can improve results, though some users report side effects.

community Study: There is 70x Higher Unconjugated DHT in Feces Compared To Blood Levels in Young Adults - Gut Microbiota Manages DHT Recycling and Metabolism

in Research/Science 197 upvotes 8 months ago

Gut microbiota significantly influences androgen metabolism, impacting hair loss treatments like finasteride. Probiotics, dietary changes, and fecal microbiota transplants may help manage DHT levels and improve hair health.

Similar Research

5 / 1000+ results

research Insulin Resistance and Polycystic Ovary Syndrome

November 2004 in “John Wiley & Sons, Ltd eBooks”

Insulin resistance is linked to PCOS and can lead to other health issues, but treatments like metformin can help manage symptoms.

research Polycystic Ovary Syndrome: A Comprehensive Review of Pathogenesis, Management, and Drug Repurposing

68 citations , January 2022 in “International Journal of Molecular Sciences”

PCOS management includes lifestyle changes and medications, with ongoing research into repurposed drugs for better treatment options.

research Metabolic and Reproductive Characteristics of First-Degree Relatives of Women with Self-Reported Oligo-Amenorrhea and Hirsutism

6 citations , October 2010 in “Gynecological Endocrinology”

Relatives of women with PCOS symptoms are more likely to have similar health issues.

research Potential Role and Therapeutic Interests of Myo-Inositol in Metabolic Diseases

369 citations , June 2013 in “Biochimie”

Myo-inositol supplements may improve insulin sensitivity and help with conditions like PCOS and gestational diabetes, but more research is needed.

research A Global Survey of Ethnic Indian Women Living with Polycystic Ovary Syndrome: Comorbidities, Concerns, Diagnosis Experiences, Quality of Life, and Use of Treatment Methods

3 citations , November 2022 in “International journal of environmental research and public health/International journal of environmental research and public health”

Ethnic Indian women with PCOS often have early symptoms, delayed diagnosis, and need better information and support for treatment and lifestyle management.