Insulin Resistance and Beta-Cell Dysfunction and the Relationship with Cardio-Metabolic Disorders Among Women with Polycystic Ovary Syndrome
September 2018
in “
Clinical Endocrinology
”
TLDR Women with PCOS have more insulin resistance and are more likely to have heart-related health issues, with insulin resistance being a bigger factor than β-cell problems.
The study, conducted on 824 women with polycystic ovary syndrome (PCOS) and 2715 non-PCOS women in China, investigated the effects of insulin resistance and β-cell dysfunction on cardio-metabolic disorders in PCOS patients. It found that PCOS women had higher insulin resistance and β-cell function indices, as well as a higher prevalence of obesity, central obesity, and dyslipidemia compared to non-PCOS women. Insulin resistance was more strongly associated with these cardio-metabolic abnormalities than β-cell dysfunction. The study concluded that insulin resistance and β-cell dysfunction independently contribute to cardio-metabolic abnormalities in women with PCOS, with insulin resistance having a more significant impact. It also highlighted the importance of early screening for insulin resistance and β-cell dysfunction in PCOS patients to prevent complications.
