Relation Between Non-Alcoholic Fatty Pancreas and Clinical and Biochemical Parameters in Women with Polycystic Ovary Syndrome: A Multi-Centric Study

    November 2022 in “ International Journal of General Medicine ”
    Mustafa AA Osman, Mohamed Alkhouly, Ghada F Elmohaseb, Eman Mostafa Nassef, Ibrahim Ghonim Ramadan Mohamed, Ismail Mohamed El Mancy, Seham Sabry, Marwa M Abdulrehim, Ahmed Eliwa, Yasmine Hamdy Eisa, Ahmed M. Abdel-Ghany, Yasser Abdelghani
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    TLDR Women with Polycystic Ovary Syndrome are more likely to have Non-Alcoholic Fatty Pancreas Disease, which is associated with older age, metabolic syndrome, insulin resistance, and high male hormone levels.
    The study involved 150 women with Polycystic Ovary Syndrome (PCOS) and 150 healthy controls, and found that Non-Alcoholic Fatty Pancreas Disease (NAFPD) was more common in women with PCOS (38.0%) than in the control group (12.0%). Women with both PCOS and NAFPD were typically older, had higher Body Mass Index (BMI), fasting blood glucose levels, total cholesterol levels, and a higher occurrence of metabolic syndrome, insulin resistance, and severe Non-Alcoholic Fatty Liver Disease (NAFLD). They also had higher testosterone levels, lower Luteinizing Hormone (LH) levels, lower Sex Hormone Binding Globulin (SHBG), and higher Free Androgen Index (FAI). The study concluded that NAFPD is prevalent in women with PCOS and is linked with older age, metabolic syndrome, insulin resistance, and hyperandrogenism.
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