Hyperandrogenism Insulin Resistance-Acanthosis Nigricans Syndrome in a Female Adolescent with Migraine: A Case Report

October 2025 in “ Indian Journal of Physiology and Pharmacology ”

Karishma Rathi, Prajwal Rao, Gayatri Sanjay Korade, Shashikanth Digambar Kharat

hyperandrogenism insulin resistance acanthosis nigricans HAIR-AN syndrome polycystic ovary syndrome obesity acne hirsutism antiandrogen therapy metformin orlistat PCOS antiandrogen Glucophage Xenical

Studysummary This case study suggests a potential connection between insulin resistance-induced diabetes and the development of migraine symptoms in a patient with HAIR-AN syndrome, highlighting the importance of early diagnosis and a multifaceted treatment approach. Our plain-language summary of this paper — not a Tressless recommendation.

This case report discusses an 18-year-old female with HAIR-AN syndrome, a severe form of polycystic ovary syndrome, who also suffers from migraines. Symptoms such as obesity, acne, hirsutism, and acanthosis nigricans began during puberty but were diagnosed later. The study suggests a link between insulin resistance-induced diabetes and migraines. Treatment included antiandrogen therapy, weight management, migraine treatment, and medications like metformin and orlistat. The report stresses the importance of early diagnosis and intervention in endocrine disorders to improve outcomes and calls for further research to enhance diagnostic and treatment strategies, particularly in adolescents.

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An Adolescent Girl with Coexisting Ovarian Mature Cystic Teratoma and HAIR-AN Syndrome, an Extreme Subtype of Polycystic Ovarian Syndrome

research An Adolescent Girl with Coexisting Ovarian Mature Cystic Teratoma and HAIR-AN Syndrome, an Extreme Subtype of Polycystic Ovarian Syndrome

2 citations , February 2021 in “Endocrinology, diabetes & metabolism case reports”

This case report describes a 15-year-old girl with severe hyperandrogenaemia linked to both an ovarian androgen-secreting tumor and HAIR-AN syndrome, highlighting the complexity of diagnosing polycystic ovarian syndrome.

research Clinical Profiles, Occurrence, and Management of Adolescent Patients with HAIR-AN Syndrome

24 citations , January 2004 in “The scientific world journal/TheScientificWorldjournal”

This study found that HAIR-AN syndrome is prevalent among young women, and a multifaceted treatment approach effectively reduces symptom severity and prevents further consequences.