Clinical Profiles, Occurrence, and Management of Adolescent Patients with HAIR-AN Syndrome

The study reviewed clinical data from an outpatient adolescent clinic and found that 5% of 1,002 young women (ages 10-21) were diagnosed with HAIR-AN syndrome, a subphenotype of polycystic ovary syndrome. The mean age of patients was 15.5 years, with an initial mean weight of 94.5 kg and a mean BMI of 33.33 kg/m². Treatment included weight stabilization and reduction, oral contraceptive pills, and metformin. Results showed that 80% of patients were compliant with treatment, 60% maintained or reduced their weight, 95% had regular menstrual cycles, and most saw improvement or no worsening in acne and hirsutism. The study concluded that HAIR-AN syndrome was common in young women and that aggressive, multifaceted treatment was effective in reducing symptoms and preventing further issues.