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    Glossary Immune Tolerance

    process where immune system avoids attacking body's own cells

    Immune tolerance is the process by which the immune system learns to recognize and not attack the body's own cells and tissues. This is crucial for preventing autoimmune diseases, where the immune system mistakenly targets the body's own cells, such as in alopecia areata where hair follicles are attacked. For professionals, it involves mechanisms like central tolerance in the thymus and peripheral tolerance in other tissues to maintain self-tolerance and prevent autoimmunity.

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    1. Ex Vivo Treatment with Allogenic Mesenchymal Stem Cells of a Healthy Donor on Peripheral Blood Mononuclear Cells of Patients with Severe Alopecia Areata: Targeting Dysregulated T Cells and the Acquisition of Immunotolerance International Journal of Molecular Sciences · 2022 · 1 citations
    2. IL-15 in alopecia areata: the immune tolerance mechanistic insights and translational perspectives Frontiers in Medicine · 2026
    3. Hair follicle immune privilege in autoimmune and immune-mediated alopecias: paths toward reestablishing immune tolerance Frontiers in Medicine · 2026
    4. Nanoparticle Adjuvants Incorporating Haptens Drive Potent Immune Tolerance to Accelerate Hair Regrowth ACS Applied Materials & Interfaces · 2025
    5. Breakdown of Immune Tolerance in AIRE-Deficient Rats Induces a Severe Autoimmune Polyendocrinopathy–Candidiasis–Ectodermal Dystrophy–like Autoimmune Disease 2018 · 26 citations
    6. Regulatory T cells: master orchestrators of immune tolerance and tissue homeostasis Frontiers in Science · 2026 · 2 citations
    7. Regulation of immune response genes in the skin of allergic and clinically tolerant individuals exposed to p‐phenylenediamine Allergy · 2024 · 4 citations
    8. Internal peacekeepers and external mediators: A new model of peripheral immune tolerance involving regulatory T cells and mesenchymal stem cells Advances in Clinical and Experimental Medicine · 2026
    9. Regulatory T cells in dominant immunologic tolerance Journal of Allergy and Clinical Immunology · 2023 · 26 citations
    10. Regulatory T cells in skin mediate immune privilege of the hair follicle stem cell niche Science Immunology · 2024 · 21 citations
    11. Mechanisms of tolerance and potential therapeutic interventions in Alopecia Areata Pharmacology & therapeutics · 2017 · 12 citations
    12. Immune-Molecular Link between Thyroid and Skin Autoimmune Diseases: A Narrative Review Journal of Clinical Medicine · 2024 · 6 citations
    13. Sequential immunotherapy for alopecia areata: phase-driven immune rebalancing Expert Review of Clinical Immunology · 2025 · 1 citations
    14. T-cell “induced-self” MHC class I/peptide complexes may enable “de novo” tolerance induction to neo-antigens occurring outside of the thymus Experimental dermatology · 2016 · 8 citations
    15. Immune therapies for alopecia areata: evidence and new perspectives Expert Review of Clinical Immunology · 2025 · 5 citations
    16. Tolerance induction by hair-specific keratins in murine alopecia areata Journal of Leukocyte Biology · 2013 · 18 citations
    17. Autoimmunerkrankungen erfordern eine kombinierte Therapie aus Toleranzinduktion und Immunsuppression - Modelluntersuchung bei der Alopecia Areata Repository KITopen (Karlsruhe Institute of Technology) · 2014
    18. Recurrent implantation failure: A comprehensive summary from etiology to treatment Frontiers in Endocrinology · 2023 · 128 citations
    19. Regulatory T Cells: the Many Faces of Foxp3 Journal of Clinical Immunology · 2019 · 125 citations
    20. Regulatory T cells in skin Immunology · 2017 · 110 citations
    21. Tissue resident and follicular Treg cell differentiation is regulated by CRAC channels Nature Communications · 2019 · 40 citations
    22. The Pathogenesis of Alopecia Areata in Rodent Models Journal of Investigative Dermatology Symposium Proceedings · 2003 · 23 citations
    23. Effective and economical cell therapy for hair regeneration Biomedicine & Pharmacotherapy · 2022 · 17 citations
    24. Allogeneic Hair Transplantation with Enhanced Survival by Anti-ICAM-1 Antibody with Short-Term Rapamycin Treatment in Nonhuman Primates 2016 · 4 citations
    25. The Multi-Faceted Role of Gut Microbiota in Alopecia Areata Biomedicines · 2025 · 3 citations
    26. Regulatory T Cells in Autoimmune Diseases and their Potential Journal of Investigative Dermatology Symposium Proceedings · 2005 · 3 citations
    27. AIRE Deficiency Leads to the Development of Alopecia Areata‒Like Lesions in Mice 2022 · 2 citations
    28. Sequential Immunotherapy with Tofacitinib and Low-Dose IL-2 Induces Sustained Remission in Alopecia Areata: A Proof-of-concept monocentric study QJM · 2025
    29. MODERN PERSPECTIVES ON THE PATHOPHYSIOLOGY OF ALOPECIA AREATA (literature review) Medical Science of Ukraine (MSU) · 2025
    30. Usos clínicos de la suplementación oral con péptidos de colágeno en la consulta dermatológica Más dermatología · 2024