UVB-Induced Depletion of Donor-Derived Dendritic Cells Prevents Allograft Rejection of Immune-Privileged Hair Follicles in Humanized Mice

    November 2018 in “ American journal of transplantation ”
    Jin Yong Kim, Byungjun Kang, Ji Su Lee, Hi Jung Park, Hae Joo Wi, Jung Ah Yoon, Curie Ahn, Sue Shin, Kyu Han Kim, Kyeong Cheon Jung, Oh Sang Kwon
    TLDR UV light helped human hair transplants survive in mice without broad immunosuppression.
    The study investigated the use of UVB irradiation combined with anti-CD154 antibody treatment to prevent allograft rejection of hair follicles (HFs) in humanized mice. By depleting donor-derived dendritic cells (DCs) through UVB preirradiation and blocking recipient-derived DCs with anti-CD154 antibody, the researchers achieved long-term survival and hair regrowth in treated groups, with significantly reduced T cell and MHC class II+ cell infiltration around the follicles. The study included 24 humanized mice and concluded that this approach could serve as a novel immunomodulatory strategy for clinical HF transplantation without the need for generalized immunosuppression.
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