UVB Irradiation with Anti-CD154 Antibody Prolonged the Survival of Hair Follicle Allografts in Humanized Mice

    April 2016 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    J. Kim, Jung Ah Yoon, Byungjun Kang, H. Park, Hae Joo Wi, Kyeong Cheon Jung, Seong Jin Jo, K. Kim, Ohsang Kwon
    TLDR Combining UVB irradiation and anti-CD154 antibody improves hair follicle transplant survival.
    The study explored a novel immunosuppressive regimen for allogeneic hair transplantation using UVB irradiation and anti-CD154 antibody in a humanized mouse model. UVB irradiation was applied to donor hair follicles before transplantation, and anti-CD154 antibody was administered to the mice post-transplantation. Results showed that the combination treatment (UVB+Ab) significantly improved the survival of hair follicle allografts compared to other groups. Histological examination revealed that the outer root sheath of hair follicles remained intact for several weeks in the UVB+Ab group, while it deteriorated quickly in the control group. Additionally, there was a reduction in infiltrating human CD3+ T cells in the UVB+Ab and Ab groups compared to the UVB and control groups. The study concluded that the combination of UVB irradiation and anti-CD154 antibody had a synergistic effect, enhancing the survival of hair follicle allografts in humanized mice.
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