Bipolar Patients and Bullous Pemphigoid After Risperidone Long-Acting Injectable: A Case Report and Literature Review

    October 2021 in “ Brain Sciences ”
    Michele Fabrazzo, M. Boccardi, Salvatore Cipolla, Raffaele Galiero, Claudia Tucci, Francesco Perris, Ester Livia Di Caprio, Francesco Catapano, Ferdinando Carlo Sasso
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    TLDR Long-term use of Risperidone may be linked to a serious skin condition in bipolar patients, affecting their overall well-being.
    The document is a case report and literature review exploring the occurrence of Bullous Pemphigoid (BP), a skin condition, in bipolar patients after long-term use of Risperidone Long-Acting Injectable (RLAI). The case study involves a 58-year-old patient who developed BP after 2 years of RLAI treatment. The literature review suggests a potential association between RLAI and BP, but the exact mechanism is unclear. The document also discusses the hypothesis that neurodegeneration or neuroinflammation might lead to a cross-reactive immune response between neural and cutaneous antigens, contributing to self-tolerance failure. The document concludes that BP comorbid with bipolar disorder could represent a serious health risk and affect patients’ physical and psychosocial quality of life, and clinicians should consider BP as a possible adverse effect of psychotropic medications.
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