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This paper introduces a new understanding that the human hair follicle medulla lacks metabolic activity for H2O2 breakdown, indicating that H2O2 decomposition occurs primarily in the cortical areas.

The research identified 12 antioxidant compounds in Polygonum multiflorum roots, suggesting these as quality markers for the plant's processed roots.

This study found that the methanolic extract of Hibiscus rosa sinensis exhibits promising 5α-reductase inhibitory activity, suggesting its potential use in the treatment of androgenic conditions like male pattern hair loss and benign prostatic hyperplasia.

In this study, researchers found that both thermolabile and thermostable forms of phenol sulfotransferase contribute to the sulfation of minoxidil, emphasizing the need to consider both enzymes in assessing sulfation in human tissues.

This study found that sebaceous glands predominantly exhibit oxidative activity of the type 2 17β-hydroxysteroid dehydrogenase isozyme, which is not inhibited by 13-cis retinoic acid.

This study found that Tanshinone I and Tanshinone IIA from Salviae Miltiorrhizae Radix inhibited Nox activity heightened by testosterone in a mouse model, reducing H₂O₂ production and cell apoptosis, and reversing testosterone-induced hair growth suppression, suggesting their potential as treatments for androgenetic alopecia.

This study found that hydrogen peroxide accumulation and reduced methionine sulfoxide repair play a significant role in the oxidative damage linked to senile hair graying.

This study found that alpha-tocopherol acetate did not demonstrate any protective effect against hair loss induced by doxorubicin in patients with solid tumors.

This study found that cyproterone acetate significantly reduced both serum 3α-AdiolG levels and hirsutism scores in women with idiopathic hirsutism, PCOS, or 21-hydroxylase deficiency, suggesting its effectiveness in treating excessive hair growth.

This study found that hinokitiol effectively suppressed TNF-α production in activated macrophage-like cells, suggesting it may help alleviate hair loss by mitigating factors that promote follicular apoptosis.

This study suggests that 5-ADIOL-S may contribute to the synthesis of potent androgens in peripheral tissues, and 3 alpha-DIOL-S could be a marker of androgen metabolism in various female patient groups.

This study found that hydroxycinnamate derivatives, especially a compound named 10a, effectively inhibited SRD5A1 activity and protein expression in cell assays, suggesting potential for treating androgen-related conditions.

This study found that compound 3, a tetrahydropyridoindole carboxymethylated at position 5, significantly inhibited sorbitol accumulation in both rat eye lenses and tissues affected by diabetes, indicating its potential as a lead compound for ALR2 inhibition.

In this study, all-trans retinoic acid was found to protect against oxidative stress-induced apoptosis in cultured hair cell-like cells.

This study found that patients with female pattern hair loss had higher oxidative stress levels and lower antioxidant enzyme activities than healthy controls, suggesting oxidative stress may play a key role in disease progression.

In this study using a mouse model, the authors reported that the synthetic antioxidant TS-13 effectively inhibited tumor growth comparably to doxorubicin and reduced chemotherapy side effects, such as weight loss, splenotoxicity, and alopecia, more effectively when combined with the cytostatic treatment.

In this study, an oleanolic acid-containing scalp treatment increased terminal hair counts significantly more than placebo in men under 50 with androgenic alopecia, but only three showed clinical improvement, with minimal side effects reported.

This study comparatively evaluated different extraction techniques for Schinus terebinthifolius Raddi leaf extracts and found that conventional extraction with ethanol yielded the highest antioxidant activity and beneficial effects on skin cell viability, supporting its potential use in sustainable cosmeceutical formulations targeting skin aging.

This study demonstrated that human hair keratins have strong antioxidative properties, providing protection against oxidative stress in human dermal fibroblasts, suggesting their potential as antioxidizing supplements.

This research observed that Backhousia citriodora leaf extract effectively reduced sebum production and improved sebum composition across different ethnicities, significantly decreasing skin oiliness and the likelihood of shiny skin when used in a cream applied twice daily for 28 days.

This study evaluated a hair tonic formulated from oil palm leaf extract, finding it demonstrated very strong antioxidant activity and could prevent hair decolorization from sun exposure, with effective concentrations ranging from 25 to 200 ppm.

This study found that α-tocopheryl acetate is well absorbed through healthy skin, with absorption occurring through specific pathways and showing high affinity for small blood vessels.

Equol may help with antiaging and skin health by boosting collagen and blocking certain hormones.

This study found that extracts from riceberry broken rice and crude riceberry rice oil contain bioactive compounds with antioxidant and tyrosinase-stimulating activities, suggesting potential use in hair product development.

This study found that forsythoside A, a compound from Forsythia suspensa, may counteract DHT-induced hair regrowth inhibition by selectively inhibiting TRPV3 channels.

This study found that a bleach bath treatment with 0.005% HOCI reduced the expression of certain serine proteases in cultured keratinocytes and lowered skin pH in atopic dermatitis patients, potentially improving symptoms by modulating the NF-kB pathway.

Two women had skin reactions from a hair loss treatment and got better after stopping use.

This study found that TRP-hair essence significantly protected and improved the quality of human hair, particularly against heat stress, by enhancing cuticle health and maintaining hair color.

In this study, the researchers reported that a newly developed PYGL inhibitor, HTPI, enhanced hair growth in an ex-vivo culture by reducing oxidative damage in hDPCs and inhibiting glycogen degradation in hORSCs, showing potential as a treatment for hair loss comparable to minoxidil.