Serum C-19 Steroid Sulphates in Females with Clinical Hyperandrogenism

January 1989 in “ Journal of Steroid Biochemistry ”

Joseph Montalto, John W. Funder, A. B. W. Yong, Annette C. Allan, Harold E. Da Vies, John F. Connelly

TLDR Women with hyperandrogenism have higher androgen levels and lower SHBG, which may contribute to conditions like excessive hair growth and early puberty.

In a study from 1989, researchers investigated serum levels of androgens and steroid sulphates in females with various forms of hyperandrogenism, including premature adrenarche (PA, n = 9–16), late onset 21 hydroxylase deficiency (LOCAH, n = 14), polycystic ovarian disease (PCOD, n = 28), idiopathic hirsutism (IH, n = 74), and androgenic alopecia (AA, n = 35–45), compared to normal prepubertal girls (n = 9-14) and normal adult women (n = 50–73). The study found elevated levels of certain androgens and a lower level of sex hormone binding globulin (SHBG) in all patient groups except for dehydroepiandrosterone sulphate (DHEA-S) and testosterone (T) in the alopecia group. The study concluded that 5-androstene-3ß,17ß-diol sulphate (5-ADIOL-S) might act as a pro-hormone in the synthesis of more potent androgens in the skin, and that 5α-androstane-3α,17ß-diol sulphate (3α-DIOL-S) could be a marker of peripheral androgen metabolism. These factors seem to play a role in hirsutism and premature pubic hair development in girls, and in androgenic alopecia, 5-ADIOL-S and free testosterone may be particularly significant.

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