Percutaneous Absorption of Alpha-Tocopheryl Acetate

    January 1968 in “ THE JOURNAL OF VITAMINOLOGY ”
    Mitsuo Kamimura, Tohru MATSUZAWA
    Image of study
    TLDR α-Tocopheryl acetate is well absorbed through healthy skin.
    The 1968 study by Kamimura and Matsuzawa examined the percutaneous absorption of α-tocopheryl acetate in 7 patients and 14 skin samples, finding it was well absorbed through healthy skin primarily via the epidermis and hair follicles. The compound showed a high affinity for small blood vessels and was notably present in hair papillae shortly after application. While it appeared in sebaceous glands, it was not detected in their immediate environment. The study suggested a potential conversion to α-tocopherol during absorption, though this was not confirmed. The findings indicated that α-tocopheryl acetate could penetrate skin layers more effectively than water-soluble substances, with no absolute barriers to its absorption.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 121 results

      community Vitamin E

       20 upvotes 6 years ago
      Vitamin E was discussed as a treatment for hair shedding, with a specific form mentioned. A user shared a link to a study and started taking the Vitamin E variants used.

      community 35% regrowth brothers and sisters! More effective than Minox and Fin?

      in Treatment  107 upvotes 6 years ago
      A double-blind clinical study that found ingestion of tocotrienols resulted in a 34.5% increase in hair regrowth compared to the placebo group, and discussion about potential side effects and cost of supplementation with vitamin E pills. The conversation noted that it may be more effective than commonly used treatments like minoxidil and finasteride.

      community Natural Remedies: Polyphenols and Hair Loss

       21 upvotes 5 years ago
      Natural remedies to treat hair loss, such as polyphenols, apple peel extract, grape seed extract, green tea extract, peppermint oil, pumpkin seed oil, apigenin, Ginkgo biloba, red clover extract, olive leaf extract, Ecklonia Cava and Grateloupia elliptica. In addition, terpenes, carotenoids, and tocopherols were discussed as potential treatments.
      FCE 28260: A Forgotten 5α-Reductase Inhibitor

      community FCE 28260: A Forgotten 5α-Reductase Inhibitor

      in Research  330 upvotes 4 months ago
      FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.

    Related Research

    1 / 1 results