Tanshinone, a Natural NADPH Oxidase Inhibitor, Mitigates Testosterone-Induced Hair Loss

    December 2024 in “ Biomolecules & Therapeutics ”
    Yeo Kyu Hur, Ji Yun Chae, Min Hye Choi … Yun Soo Bae
    Studysummary This study found that Tanshinone I and Tanshinone IIA from Salviae Miltiorrhizae Radix inhibited Nox activity heightened by testosterone in a mouse model, reducing H₂O₂ production and cell apoptosis, and reversing testosterone-induced hair growth suppression, suggesting their potential as treatments for androgenetic alopecia.
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    Research cited in this study 7

    1. Androgenetic Alopecia: An Update JAAD International · 2023
    2. A Comprehensive Review of Biochemical Factors in Herbs and Their Constituent Compounds in Experimental Studies on Alopecia Journal of Ethnopharmacology · 2020
    3. The Effectiveness of Treatments for Androgenetic Alopecia: A Systematic Review and Meta-Analysis Journal of The American Academy of Dermatology · 2017
    4. Androgenetic Alopecia: A Review Endocrine · 2017
    5. The Impact of Oxidative Stress on Hair International Journal of Cosmetic Science · 2015
    6. Molecular Basis of Androgenetic Alopecia: From Androgen to Paracrine Mediators Through Dermal Papilla Journal of Dermatological Science · 2010
    7. Review of Hair Follicle Dermal Cells Journal of Dermatological Science · 2009