Original Synthetic Monophenolic Antioxidant with Combined Effect Inhibits Tumor Growth In Vivo

    January 2025 in “ Сибирский научный медицинский журнал ”
    E. B. Menshchikova, M. V. Khrapova, П. М. Кожин, А. В. Чечушков, Е. С. Петрова, A. E. Serykh, L. P. Romakh, Н. В. Кандалинцева
    TLDR TS-13 effectively stops tumor growth and reduces chemotherapy side effects.
    The study investigated the effects of a synthetic monophenolic antioxidant, TS-13, on tumor growth and chemotherapy side effects in 120 female C57Bl/6 mice with Lewis lung carcinoma. TS-13, administered intragastrically, inhibited tumor growth as effectively as doxorubicin and showed enhanced effects when combined with it. Unlike tBHQ, TS-13 significantly reduced the negative side effects of chemotherapy, including cachexia, splenotoxicity, and alopecia. The study concluded that TS-13, as a direct antioxidant and inducer of the Keap1/Nrf2/ARE system, is comparable to doxorubicin in antitumor efficacy and can mitigate chemotherapy's adverse effects.
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