Antiaging Effects of Equol: A Unique Antiandrogenic Isoflavone Metabolite and Its Influence in Stimulating Collagen Deposition in Human Dermal Monolayer Fibroblasts

March 2005 in “ Journal of the American Academy of Dermatology ”

Edwin D. Lephart, Trent D Lund, Robert J. Handa, Kenneth D.R. Setchell, E Phosphate, Otto H. Mills, Robert Verdicchio

equol isoflavone 5α-dihydrotestosterone 5α-DHT S-equol R-equol collagen 17β-estradiol androgenetic alopecia hirsutism acne wound healing DHT testosterone estrogens

TLDR Equol may help with antiaging and skin health by boosting collagen and blocking certain hormones.

The study demonstrated that equol, a metabolite of the isoflavone daidzein, specifically binds to 5α-dihydrotestosterone (5α-DHT) but not to testosterone or estrogens. Both S-equol and R-equol enantiomers were shown to bind 5α-DHT, potentially inactivating it. In human dermal monolayer fibroblasts, equol stimulated collagen deposition more effectively than 17β-estradiol across various concentrations. These findings suggested that equol could have significant applications in human health, including antiaging effects on the skin, treatment of androgenetic alopecia, hirsutism, acne, and wound healing, due to its ability to stimulate collagen and inactivate 5α-DHT.

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