research Hidradenitis Suppurativa: A Folliculotropic Disease of Innate Immune Barrier Dysfunction?
Hidradenitis suppurativa is a skin disease caused by the breakdown of the skin's natural immune barriers, especially around hair follicles.
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60-90 / 1000+ resultsresearch The Potential of Clausena Anisata (Willd.) Hook.f. ex Benth Against Propionibacterium Acnes
Clausena anisata may be effective in treating acne due to its ability to fight bacteria, reduce inflammation, and possibly lower sebum production.
research Hesperidin from Orange Peel as a Promising Skincare Bioactive: An Overview
Hesperidin from orange peels is a promising natural ingredient for skincare due to its multiple beneficial properties.
research The Implication of Mechanistic Approaches and the Role of the Microbiome in Polycystic Ovary Syndrome: A Review
Changes in gut bacteria can contribute to the development of Polycystic Ovary Syndrome (PCOS), affecting metabolism, immunity, and causing inflammation. Treatments may involve adjusting these factors.
research Understanding the Intricate Pathophysiology of Psoriasis and Related Skin Disorders
The document delves into the intricate pathophysiology of psoriasis and its association with various skin disorders, emphasizing the role of immune dysregulation and genetic factors. Psoriasis affects 2-3% of the global population and shares mechanisms with conditions like alopecia areata and vitiligo, involving cytokines such as IL-17 and IL-23. The study highlights the importance of understanding shared pathways, such as T cell dysfunction and autophagy, to improve treatment strategies. It also discusses the potential benefits of therapies like omalizumab and biologics, while noting the need for further research into the co-occurrence of psoriasis with other autoimmune disorders and the impact of environmental factors like stress and the skin microbiome.
research Transcriptome Meta-Analysis Confirms the Hidradenitis Suppurativa Pathogenic Triad: Upregulated Inflammation, Altered Epithelial Organization, and Dysregulated Metabolic Signaling
The research confirms that Hidradenitis Suppurativa is characterized by increased inflammation, disrupted skin cell organization, and abnormal metabolic processes.
research Bioinformatics and Network Pharmacology Identify the Therapeutic Role and Potential Mechanism of Melatonin in Alzheimer's Disease and Rosacea
Melatonin could be an effective treatment for Alzheimer's Disease and rosacea.
research Association Between Mesenchymal Stem Cells and COVID-19 Therapy: Systematic Review and Current Trends
Using mesenchymal stem cells or their exosomes is safe for COVID-19 patients and helps improve lung healing and oxygen levels.
research Cannabinoid Compounds as a Pharmacotherapeutic Option for the Treatment of Non-Cancer Skin Diseases
Cannabinoids like CBD and THC may help treat non-cancer skin diseases, but more research is needed.
research Wound Microbiota and Its Impact on Wound Healing
Wound healing is greatly affected by the types of bacteria present, which can either help or hinder the process.
research Enzymes
Enzymes are classified into six types and are essential for many biological processes, with only a few targeted by drugs.
research Lawsonia Inermis L.: An Updated Review Of The Ethnobotanical, Phytochemical, Pharmacological, And Toxicological Aspects In Unani Medicine
Henna has many medicinal uses but needs more research to confirm its benefits.
research Perilla Frutescens: A Rich Source of Pharmacologically Active Compounds
Perilla frutescens, an East Asian plant, contains 400 bioactive compounds that have various health benefits, including anti-inflammatory, antidepressant, and anticancer effects, and can treat conditions like diabetes, skin allergies, and neurological disorders.
research A Nude Mouse Model of Hypertrophic Scar Shows Morphologic and Histologic Characteristics of Human Hypertrophic Scar
Nude mice with grafted human skin developed scars similar to human hypertrophic scars.
research Anatomy and Function of the Skin
The skin is the largest organ, protecting the body, regulating temperature, and producing hormones.
research Inhalation Therapy for Repairing Damaged Elastin Fibers and Decelerating Elastinolysis in Chronic Obstructive Pulmonary Disease
Inhalation therapy may repair and protect elastin in the lungs of COPD patients.
research Skin Connective Tissue and Aging
Menopause reduces skin collagen and elasticity, and while estrogen therapy can help, its risks require careful consideration.
research A Current Review of the Cutaneous Manifestations of Renal Disease
Skin problems are very common in people with end-stage kidney disease.
research Drug Repurposing: Hypothesis, Molecular Aspects, and Therapeutic Applications
Drug repurposing is a cost-effective way to find new uses for existing drugs, speeding up treatment development.
research Stem Cells and Aberrant Signaling of Molecular Systems in Skin Aging
Skin aging is caused by stem cell damage and can potentially be delayed with treatments like antioxidants and stem cell therapy.
research The Use of Adipose-Derived Stem Cells in Selected Skin Diseases (Vitiligo, Alopecia, and Nonhealing Wounds)
Adipose-derived stem cells show promise in treating skin conditions like vitiligo, alopecia, and nonhealing wounds.
research Atlas of Geriatric Dermatology
The book details skin conditions in older adults, their link to mental health, cancer treatment importance, hair loss remedies, and managing autoimmune and itchy skin.
research Clinical Efficacy of Silk Sericin Dressing with Collagen for Split-Thickness Skin Graft Donor Site Treatment
Silk sericin dressing with collagen heals wounds faster and improves scar quality better than Bactigras.
research Follicle Hormones
Follicle Stimulating Hormone is important for fertility.
research Rosmarinus Officinalis and Skin: Antioxidant Activity and Possible Therapeutic Role in Cutaneous Diseases
Rosemary may help treat various skin conditions due to its antioxidant and anti-inflammatory properties.
research Current Insight of Peptide-Based Hydrogels for Chronic Wound Healing Applications: A Concise Review
Peptide-based hydrogels are promising for healing chronic wounds effectively.
research Exosomal MicroRNA-Based Therapies for Skin Diseases
miRNA-based therapies show promise for treating skin diseases, including hair loss, in animals.
research Aligned membranes regulate wound healing via MMP12 secreted by macrophages
The study explores the impact of aligned electrospinning membranes on wound healing, emphasizing the role of MMP12 secreted by macrophages. Through in vivo and in vitro experiments using a mouse model, the research shows that these membranes enhance wound healing by upregulating MMP12, which inhibits fibroblast migration and reduces scar formation. The aligned membranes create a regenerative microenvironment that promotes efficient, scar-free healing, with increased hair follicle regeneration and organized collagen deposition. Single-cell RNA sequencing identified MMP12 overexpression in a macrophage subcluster, enhancing phagocytosis and modulating immune responses. The study suggests that these membranes could be used to develop advanced biological dressings for improved skin repair outcomes.
research Insertional Mutation of the Hairless Locus on Mouse Chromosome 14
A gene mutation in mice causes permanent hair loss and skin issues.
research Hopes and Limits of Adipose-Derived Stem Cells and Mesenchymal Stem Cells in Wound Healing
ADSCs help in wound healing and skin regeneration but need more research for full understanding.