3 citations,
July 2022 in “Brain and Behavior” This study investigates the pathogenesis of CARASIL using a mouse model with the HtrA1L364P mutation. Behavioral tests showed significant cognitive impairments in the mutant mice compared to wild-type mice (p < 0.001). Pathological analysis revealed structural abnormalities in brain arterioles, reduced synapses, thickened vessel walls, and other cellular anomalies. Molecular studies indicated increased mRNA and protein levels of TGF-β, Smad2, and Smad3 in the mutant mice's brains. The findings suggest that the TGF-β/Smad signaling pathway is abnormally upregulated in CARASIL, contributing to cognitive dysfunction and vascular damage. This model provides a valuable tool for exploring CARASIL pathogenesis and potential therapies.
1 citations,
September 2023 in “Frontiers in Genetics” This case report describes a 43-year-old female with a heterozygous mutation in the HTRA1 gene (905G>A, Arg302Gln) who exhibited all typical features of CARASIL, including baldness, recurrent ischemic strokes, lumbago, headache, and dementia, along with severe clinical symptoms and rapid progression. Despite heterozygous mutations usually being non-pathogenic or causing milder symptoms, this patient experienced significant cognitive decline, motor function loss, and was bedridden for over a year. The findings suggest that heterozygous mutations in HTRA1 can also result in typical CARASIL features, expanding the understanding of the disease.
December 2015 in “Vascular Pharmacology” Different cells affect hair follicle blood vessels, endothelial cells react differently to inflammation and oxidized fats, and prasugrel better protects heart vessels during a procedure than clopidogrel.
December 2015 in “Vascular Pharmacology” Prasugrel is better than clopidogrel at preventing heart damage and improving blood flow in small heart vessels during heart artery procedures.
66 citations,
May 2021 in “Science Advances” Different scaffold patterns improve wound healing and immune response in mouse skin, with aligned patterns being particularly effective.
18 citations,
July 2014 in “Molecular Medicine Reports” UVB radiation changes the levels of certain microRNAs in skin cells, which may affect cell survival and hair growth.
13 citations,
May 2022 in “Cell discovery” The study found new details about human hair growth and suggests that preventing a specific biological pathway could potentially treat hair graying.
2 citations,
December 2019 in “Journal of The European Academy of Dermatology and Venereology” Differences in gene expression and methylation patterns found in AGA patients suggest potential targets for future treatments.
New insights into cell communication in psoriasis suggest innovative drug treatments.
December 2015 in “Vascular Pharmacology” Hair papilla cells are crucial for blood vessel development in hair follicles, affecting hair growth and loss.
August 2015 in “MOJ proteomics & bioinformatics” ePUKs could be valuable for regenerative medicine due to their wound healing abilities.
130 citations,
March 2014 in “Proceedings of the National Academy of Sciences of the United States of America” Epidermal Wnt/β-catenin signaling controls fat cell formation and hair growth.
51 citations,
October 2019 in “Cells” Baricitinib reduces inflammation and improves cell health in premature aging cells.
37 citations,
May 2018 in “Frontiers in physiology” Certain RNA molecules are important for the development of wool follicles in sheep.
25 citations,
June 2022 in “Developmental cell” Overactivating Hedgehog signaling makes hair follicle cells in mice grow hair faster and create more follicles.
December 2022 in “Biochemical and Biophysical Research Communications” This study investigated the role of HtrA2 serine protease activity in hair cycle regulation using mnd2 mutant mice. The researchers observed that mnd2 mice exhibited a delay in the transition from the telogen to anagen phase of the hair cycle, which was associated with a differential skin color change compared to wild-type mice. Histological and molecular assays revealed that HtrA2 inactivation led to growth retardation of adipocytes in the subcutaneous skin layer, contributing to the delayed hair cycle. These findings highlight the essential role of HtrA2 in regulating the adipogenesis-associated hair cycle.
474 citations,
January 2012 in “Chemistry & biology” Proteasome inhibitors are promising treatments for various cancers, autoimmune diseases, and other conditions.
74 citations,
October 1998 in “Journal of biological chemistry/The Journal of biological chemistry” The 190-kbp domain contains all human type I hair keratin genes, showing their organization and evolution.
51 citations,
November 2011 in “British Journal of Dermatology” A gene called HDAC9 might be a new factor in male-pattern baldness.
48 citations,
June 2020 in “Current Rheumatology Reports” Different types of fibroblasts play various roles in both healthy and diseased tissues, and understanding them better could improve treatments for fibrotic diseases.
42 citations,
August 2007 in “Journal of Biological Chemistry” Most Hairless gene mutations reduce its ability to work with the Vitamin D Receptor, which might explain a certain type of hair loss.
28 citations,
January 2012 in “Biological & pharmaceutical bulletin” Hairless protein can both repress and activate vitamin D receptor functions, affecting gene regulation.
27 citations,
June 2013 in “Genes & development” Cav1.2 affects hair growth and could be a target for hair loss treatments.
26 citations,
September 2018 in “Colloids and Surfaces B: Biointerfaces” A new liposome treatment helps heal deep burns on mice by improving hair regrowth and reducing scarring.
13 citations,
November 2013 in “Journal of Endocrinology/Journal of endocrinology” Vitamin D receptor helps control hair growth genes in skin cells.
12 citations,
April 2014 in “Molecular Medicine Reports” Targeting specific miRNAs may help treat hair follicle issues caused by hydrogen peroxide.
9 citations,
April 2019 in “Molecules” Blackcurrant extract may help reduce hair loss by promoting stem cell activity in hair follicles.
7 citations,
November 2022 in “Communications biology” Keratin injections can promote hair growth by affecting hair-forming cells and tissue development.
7 citations,
October 2018 in “BMC genomics” Key genes can rewire networks, changing skin appendage types.
7 citations,
August 2017 in “PloS one” Key genes linked to hair growth and cancer were identified in hairless mice.