Delayed Hair Cycle in Mnd2 Mutant Mice Lacking HtrA2 Serine Protease Activity

    December 2022 in “ Biochemical and Biophysical Research Communications ”
    Min-Kyung Nam, Hyun-Ah Shin, Heejae Yun … Hyangshuk Rhim
    Studysummary This study found that HtrA2 inactivation in mnd2 mice is associated with delayed hair cycle phases and growth retardation of adipocytes, suggesting HtrA2's role in regulating adipogenesis-related hair growth.
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    Research cited in this study 7

    1. Morphogenesis, Growth Cycle, and Molecular Regulation of Hair Follicles Frontiers in Cell and Developmental Biology · 2022
    2. The Role of Immature and Mature Adipocytes in Hair Cycling Trends in Endocrinology and Metabolism · 2018
    3. Epidermal Growth Factor Induces Proliferation of Hair Follicle-Derived Mesenchymal Stem Cells Through Epidermal Growth Factor Receptor-Mediated Activation of ERK and AKT Signaling Pathways Associated With Upregulation of Cyclin D1 and Downregulation of p16 Stem Cells and Development · 2016
    4. Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling Cell · 2011
    5. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    6. The Hair Cycle Journal of Cell Science · 2006
    7. The Secret Life of the Hair Follicle Trends in genetics · 1992