December 2022 in “Biochemical and Biophysical Research Communications” This study investigated the role of HtrA2 serine protease activity in hair cycle regulation using mnd2 mutant mice. The researchers observed that mnd2 mice exhibited a delay in the transition from the telogen to anagen phase of the hair cycle, which was associated with a differential skin color change compared to wild-type mice. Histological and molecular assays revealed that HtrA2 inactivation led to growth retardation of adipocytes in the subcutaneous skin layer, contributing to the delayed hair cycle. These findings highlight the essential role of HtrA2 in regulating the adipogenesis-associated hair cycle.
218 citations,
September 2014 in “Experimental Dermatology” Skin fat cells help with skin balance, hair growth, and healing wounds.
August 2023 in “International Journal of Molecular Sciences” Human skin xenografting could improve our understanding of skin development, renewal, and healing.
9 citations,
October 2013 in “Drug Delivery” Ethosomal carriers effectively deliver hair loss drug into skin.
1 citations,
July 2005 in “Drugs and the pharmaceutical sciences” Targeting drugs to hair follicles can treat skin conditions, but reaching deep follicle areas is hard and needs more research.