Proteins in Scalp Hair of Preschool Children

January 2024 in “ Psych ”

Cynthia R. Rovnaghi, Kratika Singhal, Ryan D. Leib, Maria Xenochristou, Nima Aghaeepour, Allis Chien, Deendayal Dinakarpandian, Kanwaljeet J. S. Anand

scalp hair proteins SERPINB4 PLEC SCGB2A1 biomarkers protein expression developmental changes health status

TLDR Hair proteins in preschool children and their mothers could indicate developmental changes and health status.

The study analyzed scalp hair proteins from 40 preschool children and 43 mothers, identifying significant individual variability and age-related differences in protein expression. Mothers had higher protein counts and more diverse proteins than children, with specific proteins like SERPINB4 and PLEC more abundant in mothers, and SCGB2A1 higher in children. The top 5% of proteins influencing variability were linked to brain development, immune signaling, and stress response. The findings suggest that non-structural hair proteins could serve as biomarkers for monitoring developmental changes and health status in early childhood, despite limitations like a small sample size and semi-quantitative data.

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