1 citations,
September 2023 in “Acta dermato-venereologica” Certain genetic variants are linked to frontal fibrosing alopecia in Spanish patients.
2 citations,
July 2022 in “Frontiers in Medicine” The cause of Frontal fibrosing alopecia, a type of hair loss, is complex, likely involving immune responses and genetics, but is not fully understood.
1 citations,
September 2021 in “CRC Press eBooks” Frontal Fibrosing Alopecia is a hair loss condition mainly affecting postmenopausal women, with unclear causes and various clinical patterns.
7 citations,
January 2019 in “Australasian Journal of Dermatology” A genetic marker linked to a type of hair loss was found in most patients studied.
May 2024 in “JAMA Dermatology” This study examined the interaction between the CYP1B1 gene variant (c.1358A>G, p.Asn453Ser) and oral contraceptive pill (OCP) use on the risk of frontal fibrosing alopecia (FFA) in 489 female patients and 34,254 controls. It found that the presence of an asparagine residue at position 453 of CYP1B1 was associated with a 1.9 times greater risk of FFA in OCP users, but no effect was observed in non-users. This suggests that OCP use may increase FFA risk in carriers of the CYP1B1 risk allele, emphasizing the role of gene-environment interactions in FFA pathogenesis.
3 citations,
July 2023 in “Biomolecules” B2m-free HLA variants may be a new class of HLA important in immune responses and diseases.
1 citations,
July 2023 in “Journal of the European Academy of Dermatology and Venereology” Portraits show women's hairlines have moved forward over time, suggesting changes in the occurrence of frontal hair loss.
The study investigated protein expression in forehead epidermal corneocytes to distinguish between frontal fibrosing alopecia (FFA) and androgenetic alopecia (AGA). Samples from 5 FFA patients, 5 AGA patients, and 12 controls revealed that FFA had 72 proteins significantly different from controls, with most showing lower expression, while AGA had only 3 proteins significantly different. This suggests FFA affects protein expression systemically, beyond the scalp. The findings support non-invasive monitoring of FFA through forehead epidermis protein profiling, indicating a potential for better diagnosis and treatment monitoring.
2 citations,
June 2021 in “Sultan Qaboos University medical journal” Familial frontal fibrosing alopecia is rare, mostly affects women, and often occurs between sisters or mother-daughter pairs.
January 2020 in “Revista da Sociedade Portuguesa de Dermatologia e Venereologia” Frontal fibrosing alopecia in Brazil mostly affects postmenopausal women, often linked with hypothyroidism and eyebrow hair loss.
4 citations,
May 2021 in “Biomedicines” Targeting the protein Caveolin-1 might help treat a type of scarring hair loss called Frontal Fibrosing Alopecia.
11 citations,
February 2021 in “Biomedicines” Bacteria in our hair can affect its health and growth, and studying these bacteria could help us understand hair diseases better.
23 citations,
April 2021 in “Journal of Clinical Medicine” Frontal Fibrosing Alopecia's cause is unclear, affects mainly postmenopausal women, and current treatments focus on stopping hair loss rather than regrowth.
9 citations,
July 2020 in “Journal of Dermatology” Asian patients with Frontal Fibrosing Alopecia often lose eyebrow hair and respond well to combined antiandrogen or antimalarial and topical treatments.
8 citations,
October 2019 in “International Journal of Dermatology” The study concluded that combination therapy with topical corticosteroids and hydroxychloroquine or finasteride is effective in treating Frontal fibrosing alopecia in Asians.
6 citations,
October 2020 in “Journal of Cellular and Molecular Medicine” 3D culture helps maintain hair growth cells better than 2D culture and identifies key genes for potential hair loss treatments.
3 citations,
November 2020 in “Clinical, Cosmetic and Investigational Dermatology” Early diagnosis and combination therapy, especially with finasteride and dutasteride, are key to managing Frontal Fibrosing Alopecia effectively.
2 citations,
January 2019 in “Skin appendage disorders” Higher social status is linked to earlier diagnosis and better treatment results for Frontal Fibrosing Alopecia in women.
Genetic testing can help diagnose skin conditions but needs more research for full effectiveness.
The article suggests that patients with Frontal Fibrosing Alopecia may have more contact allergies, but it doesn't prove that allergies cause the condition.
October 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” A protein called EGFR protects hair follicle stem cells, and when it's disrupted, hair follicles can be damaged, but blocking certain pathways can restore hair growth.
3 citations,
October 2021 in “Journal of Cosmetic Dermatology” Trichoscopy helps tell apart Frontal Fibrosing Alopecia and Lichen planopilaris by showing different hair and scalp features.
1 citations,
January 2024 in “Journal of personalized medicine” Hormonal imbalances during menopause may significantly contribute to Frontal Fibrosing Alopecia.
8 citations,
July 2020 in “Clinical, cosmetic and investigational dermatology” Excessive sun protection might cause frontal fibrosing alopecia by disrupting skin immune balance.
4 citations,
January 2020 in “Skin appendage disorders” A woman with an unusual pattern of hair loss was confirmed to have Frontal Fibrosing Alopecia and treated with specific medications.
45 citations,
April 2019 in “International Immunology” The study concluded that immune cells attacking hair follicles cause hair loss in alopecia, with genetics and environment also playing a role, and highlighted the potential of certain treatments.
4 citations,
November 2021 in “Biomedicines” New digital tools are improving the diagnosis and understanding of irreversible hair loss conditions.
May 2023 in “Journal of Clinical Medicine” New understanding and treatments for hair loss are improving, but more research is needed.
August 2021 in “Annals of Agricultural and Environmental Medicine” The article concludes that understanding Frontal Fibrosing Alopecia (FFA) is crucial for effective treatment, which includes medication like 5α-reductase inhibitors and hydroxychloroquine.
88 citations,
August 2019 in “Nature communications” Researchers found a specific immune receptor in patients that causes severe skin reactions to a drug.