Gene-Environment Interaction Between CYP1B1 and Oral Contraception on Frontal Fibrosing Alopecia

Frontal fibrosing alopecia (FFA) is a form of irreversible hair loss mainly affecting postmenopausal individuals. A genome-wide meta-analysis identified several genetic risk factors, including HLA-B*07:02, ST3GAL1, and SEMA4B, which are involved in immune response. The gene CYP1B1, crucial for hormone metabolism, was also found to have a protective variant (p.Asn453Ser) against FFA. Understanding the interaction between genetic factors like CYP1B1 and environmental factors such as oral contraception can enhance knowledge of FFA pathogenesis and aid in developing risk mitigation strategies.