Navigating Diagnostic Uncertainty: Frontal Fibrosing Alopecia Versus Keratosis Pilaris Atrophicans Faciei With Genetic Testing Insights

    April 2024 in “ Curēus ”
    Deesha Desai, Ambika Nohria, Jerry Shapiro, Kristen I. Lo Sicco
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    TLDR Genetic testing can help diagnose skin conditions but needs more research for full effectiveness.
    This case study discusses the diagnostic difficulties in distinguishing between keratosis pilaris atrophicans faciei (KPAF) and frontal fibrosing alopecia (FFA) due to similar symptoms, such as bilateral eyebrow loss and facial papules. A 36-year-old male patient with these symptoms tested negative for the DSG-4 mutation linked to KPAF. The study emphasizes the potential of genetic testing to enhance diagnostic precision and treatment outcomes, though it also highlights the need for further research to fully determine its effectiveness in managing these dermatological conditions.
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