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The document concludes that while there are promising methods to control CRISPR/Cas9 gene editing, more research is needed to overcome challenges related to safety and effectiveness for clinical use.

The TRPV3 channel structure changes linked to severe itch and hyperkeratosis were identified using cryo-EM.

TRPV3 could be a target for treating pain, skin disorders, and hair problems, but more research is needed to create effective drugs.

Lower pH straighteners change hair more but weaken it.

TRP channels in the skin are important for sensation and health, and targeting them could help treat skin disorders.

Keratinocytes help keep hair follicle cells and skin cells separate in 3D cultures, which is important for hair growth research.

Softer hydrogel surfaces help maintain hair growth-related functions in skin cells.

Chinese medicine may help treat hair loss by affecting genes and enzyme activity.

The TRPV3 ion channel is important for skin and hair health and could be a target for treating skin conditions.

New CRISPR/Cas9 variants and nanotechnology-based delivery methods are improving cancer treatment, but choosing the best variant and overcoming certain limitations remain challenges.

Finasteride, a drug used for certain conditions, can cause serious side effects like sexual dysfunction, suicidal thoughts, and increased diabetes risk, and there's a need for more awareness and research about these effects.

TRPV4 helps cells repair tissue and reduce scarring by controlling calcium levels.

Oxidative stress worsens PCOS by damaging cells and disrupting metabolism, suggesting antioxidant treatments might help.

Home-use cosmetic laser and light devices show modest results for hair removal and acne treatment, but more research is needed for confirmation.

At-home laser and light skin devices are less effective than professional ones, with limited scientific evaluation, but some show promise for wrinkles, hair growth, and acne.

Turning off the Lhx2 gene in mouse embryos leads to slower wound healing and scars.

Fetal sheep develop skin nerve pathways and responses to touch and heat between 75 and 134 days of gestation.

Dihydrotestosterone (DHT) doesn't affect rat skin cell growth, but it does change cell cycle, protein levels, and other cell functions, potentially shortening hair growth cycle.

Skin fat helps with body temperature control and has other active roles in health.

CRISPR/Cas9 has improved precision and control but still faces clinical challenges.

Alopecia areata involves immune activation in the scalp, suggesting treatments targeting TH1, TH2, and IL-23 pathways.

STAT5 activation is crucial for starting the hair growth phase.

Certain essential oils can activate a human skin receptor, potentially helping with skin disorders.

Activating TRPV3 channels stops hair growth by killing hair follicle cells.

A 3-month treatment improved PCOS symptoms and reduced certain immune proteins.

Repeated use of protein hair conditioner with heat or gamma irradiation can harm skin and hair health in rats.

Activating TRPV3 stops human hair growth.

The genes OVOL1 and OVOL2 are important for hair growth and may be involved in a type of skin tumor.

Testosterone helps human pancreatic cells increase insulin release.

Faulty inflammasome activation may lead to autoimmune skin diseases and could be a target for new treatments.