Downregulation of Lhx2 Markedly Impairs Wound Healing in Mouse Fetus
August 2022
in “
Biomedicines
”
TLDR Turning off the Lhx2 gene in mouse embryos leads to slower wound healing and scars.
The study examines the role of Lhx2 in wound healing during different embryonic stages in mice, finding that Lhx2 is crucial for cell division and proper wound repair. Lhx2 was not expressed at embryonic day 13 (E13) but was present at E15 and E17. Knockdown of Lhx2 at E15 significantly delayed wound healing, led to larger scars, and resulted in the loss of hair follicles. These findings suggest that targeting Lhx2 could be a potential therapeutic strategy for improving wound healing and reducing scarring.
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