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This study found that GDNF promotes hair formation and skin wound repair by enhancing the self-renewal and differentiation of bulge stem cells in mice.

This study found that JAM-A modification in mouse wound models significantly promoted wound healing and fibroblast proliferation, potentially linked to increased levels of growth factors bFGF and EGF.

In this review, the authors describe how glucose metabolism supports various stages of wound healing by providing energy and necessary substances, noting that abnormal glucose metabolism in chronic wounds increases oxidative stress and inflammation, significantly hindering healing.

In this study on a preclinical mice model, the researchers reported that a chitosan nanogel with Mn₃O₄ nanoparticles facilitated scarless wound healing by regulating reactive oxygen species and influencing signaling molecules throughout the healing stages.

This review discusses the similarities between wound healing and embryonic development, focusing on signaling pathways and their potential for developing new wound healing strategies, and reports no new clinical results.

In this study, researchers used patient-derived organoids to model metastasis in colorectal cancer and discovered that cancer cells temporarily switch to a wound-healing program, orchestrated by reduced EZH2 activity and YAP signaling, before spreading to new organs.

This review examines advancements in "smart" hydrogel dressings for complex wound healing, highlighting innovations in materials that provide multifunctionality, such as responsive drug delivery and regenerative capabilities. The study also addresses potential challenges in clinical application, like manufacturing and regulatory hurdles.

This review highlights the potential of inorganic nanoparticle-based scaffolds as innovative tools for advanced wound care, emphasizing their ability to provide antimicrobial action and regenerative support, while also discussing fabrication strategies and challenges in optimizing their clinical application.

This study found that hair follicle transplantation improved wound healing in diabetic mice by promoting tissue regeneration and reducing inflammation, with follicles from normoglycemic conditions proving more effective than those from hyperglycemic environments.

In a rodent study, a flexible, self-powered triboelectric nanogenerator wound patch combining electrostimulation and photothermal effects was found to efficiently accelerate wound healing and hair follicle regeneration.

This study developed a GelMA-based hydrogel system that supports all stages of severe burn wound healing by reducing inflammation and enhancing tissue regeneration, including neovascularization and hair follicle growth, potentially improving clinical outcomes for complex wounds with multidrug-resistant bacterial infections.

This study suggests that incorporating matrisomal components into biomaterials could enhance skin wound healing in mammals that do not naturally regenerate tissues like the axolotl and Acomys.

This study concluded that shikonin, a small molecule derived from herbal extract, promotes wound healing and reduces inflammation in mice by activating the PI3K/Akt signaling pathway.

This study found that hair follicles in mice and humans can convert wound-related myofibroblasts into adipocytes, suggesting a potential pathway to reduce scar formation by activating BMP signaling.

The researchers reported that mesenchymal stem cells promote wound healing by using Cx43 hemichannels to mediate ATP secretion, which supports macrophage polarization, angiogenesis, and fibroblast migration, suggesting a potential therapeutic strategy for improving tissue repair.

This study identified PTEN as a key regulator in non-healing venous leg ulcers, suppressing immune responses and lymphangiogenesis, suggesting its potential as a therapeutic target for promoting VLU healing.

This study found that activation or inhibition of Wnt/β-catenin and Notch signaling pathways in rats can alter wound healing, possibly by affecting epidermal stem cell activity and keratinocyte behavior.

This study found that a new topical nitric oxide gel significantly accelerated burn wound healing in mice by enhancing re-epithelialization, hair follicle regeneration, collagen deposition, and angiogenesis compared to controls.

This study found that simvastatin interfered with insulin-induced VEGF expression and keratinocyte proliferation during skin repair in mice, effects that could be reversed by mevalonate.

The hydrogel dressing speeds up and improves diabetic wound healing.

This study found that "micro skin tissue columns" improved wound healing by enhancing re-epithelialization, collagen deposition, dermal remodeling, and reducing inflammation without causing long-term donor site morbidity.

This review discusses the use of inorganic-based biomaterials for hemostasis and wound healing, including various preparation methods and mechanisms, but reports no new clinical results.

This study reports that a pH-responsive nanosilver platform improved wound healing in mouse and rabbit models by targeting bacteria and supporting tissue repair more effectively than traditional silver nanoparticles.

This review discusses how polymer- and lipid-based nanostructures can enhance wound healing by addressing issues like microbial contamination and inflammation, though it reports no new clinical results.

This study found that endogenous EGF may facilitate the healing of second-degree scald wounds in mice through autocrine, paracrine, and endocrine mechanisms.

This review discusses the potential of peptide-based hydrogels as biomaterials for treating chronic wounds and reports no new clinical findings.

This review explores the challenges of treating chronic wounds and highlights regenerative medicine as a promising approach, emphasizing the roles of growth factors, stem cell therapies, and novel regenerative treatments in improving wound healing and tissue regeneration.

Glycogen levels in mouse skin drop after injury but increase during healing, returning to normal within a month.

This thesis argues that digital content creation in the homespace empowers Black women with natural hair by fostering community and transformative healing through the practice of testifying.

In this study, researchers developed a novel bio-patch from decellularized freeze-dried tumor tissues and hair melanin nanoparticles, which demonstrated enhanced wound healing in vivo by reducing oxidative stress, suppressing inflammation, and promoting angiogenesis.