Tsukushi Is Involved in Wound Healing by Regulating the Expression of Cytokines and Growth Factors

August 2014 in “ Journal of Cell Communication and Signaling ”

Daisuke Niimori, Rie Kawano, Kanako Niimori-Kita, Hironobu Ihn, Kunimasa Ohta

Tsukushi cytokines growth factors TGF-ß1 IL-6 Stat3 macrophages myofibroblasts inflammation

TLDR Tsukushi helps control inflammation and aids in wound healing.

In the 2014 study, researchers found that Tsukushi (TSK), a small leucine-rich proteoglycan, plays a role in wound healing by regulating the expression of cytokines and growth factors. They observed a shift in TSK expression from macrophages to myofibroblasts during the healing process in TSK-lacZ knock-in mice. The study showed that TSK inhibits TGF-ß1 secretion from macrophages, affecting macrophage function and myofibroblast differentiation. In TSK-null mice, increased levels of TGF-ß1, IL-6, and Stat3 were noted, indicating that TSK deficiency may lead to excessive inflammation. The conclusion was that TSK helps maintain the quiescence of inflammatory cells, thereby contributing to the wound healing process. The exact number of mice used in the study was not mentioned.

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