This study found that ethanolic extract and fractions of Ceiba leaf tonic may enhance rabbit hair growth similarly to 2% minoxidil.
May 2024 in “Jurnal Penelitian Farmasi dan Herbal” In this experimental study using male rabbits, researchers found that a 7.5% concentration of green tea leaf ethanol extract hair tonic was nearly as effective in promoting hair growth as the positive control, minoxidil, over a 21-day period.
January 2020 in “Archives of Pharmacy Practice” This study found that Hibiscus rosa-sinensis leaf extract promoted hair growth in rats more effectively than its flower extract, suggesting its potential as a natural alternative for hair growth treatments.
This narrative review examined the potential of hibiscus leaves and apple skin as natural ingredients for hair tonics and reported their effectiveness in addressing hair loss, highlighting properties like strong antioxidant content and ability to strengthen hair roots.
1 citations
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August 2019 In this study, a hair tonic formulation with 25% ethanol extract of mangkokan leaves showed effectiveness in promoting hair growth, as measured by significant differences in hair length and weight compared to the control.
July 2024 in “Jurnal Pengabdian Masyarakat Putri Hijau” This study involved educating Dewantara Husada Health Vocational High School students about using meniran leaf extract in pomade formulations as a hair growth stimulant, demonstrating high engagement and interest in the topic.
1 citations
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January 2019 This study found that a hair tonic combining fragrant pandan and celery extracts increased hair length in guinea pigs, with the 1:5 concentration showing the best growth activity.
June 2021 in “Journal of Pharmaceutical Care Anwar Medika” This study investigated the physical stability of hair tonic formulations made from ethanol extract of cayenne pepper leaves, finding that formulations with specific concentrations of propylene glycol and ethanol had good physical stability.
1 citations
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December 2018 in “JURNAL PENDIDIKAN DAN KELUARGA” This study found that using senseviera hair tonic significantly increased hair density among women aged 19-25 who wear hijabs.
December 2025 in “eTheses of Maulana Malik Ibrahim State Islamic University (Maulana Malik Ibrahim State Islamic University)” This study found that an optimal combination of ethnomedicinal extracts from East Nusa Tenggara, Indonesia, significantly increased hair length in mice, suggesting potential as a natural agent for hair growth through antioxidant mechanisms.
2 citations
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April 2019 in “DOAJ (DOAJ: Directory of Open Access Journals)” This study found that lotion containing ethanolic extract of Phyllanthus niruri and 1% menthol enhanced hair growth in white Wistar rats more than a formula without menthol, although not significantly.
September 2008 in “Hair transplant forum international” This commentary relates an anecdote about a patient seeking a more affordable hair transplant, but reports no new research findings.
11 citations
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October 2002 in “Genetics” This study mapped a spontaneous mouse hair mutation, "hague," to keratin genes on chromosome 15 but found no gene mutations in hague mice.
July 2012 in “Ubaya Repository (University of Surabaya)” This study found that hair growth gel and tonic containing red grape seed extract were physically and chemically unstable under high temperature and humidity conditions over 30 days.
This study found that creambath preparations with waru leaf extract accelerated hair growth in New Zealand White rabbits, though none matched the positive control; the 37.5% concentration increased hair weight effectively.
June 2022 in “Jurnal Health Sains” This review discusses plant-based alternatives for hair tonic formulations to address hair loss and contains no new clinical results, advocating for plant extracts as safer options than synthetic ingredients.
January 2022 in “Buletin penelitian tanaman rempah dan obat/Bulletin komunikasi penelitian tanaman rempah dan obat” This study observed that a hair tonic containing 3% ethanolic extract of bidara leaves stimulated rabbit hair growth more effectively over 28 days than both distilled water and 2% minoxidil, attributing this effect to the extract's anti-inflammatory and antioxidant properties.
November 2024 in “Majalah Farmasetika” In this study, the researchers explored a hair dye gel formulated with Indonesian native plant extracts and found it produced stable brown shades on bleached hair, with the most preferred dark brown achieved at a 12% concentration, and showed no skin irritation.
6 citations
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January 2006 This study suggests that dermal adipocytes play a significant role in skin aging, particularly through the process of adipocyte-myofibroblast transition, highlighting them as potential targets to combat aging in chronically photo-damaged skin.
HEM-13HDC, a mix of 8 herbal extracts, helps hair grow and affects hair growth at a molecular level.
December 2025 in “eTheses of Maulana Malik Ibrahim State Islamic University (Maulana Malik Ibrahim State Islamic University)” This study found that the highest antioxidant-activity formulation of the RENTT herbal combination effectively stimulated hair growth in mice and may serve as a natural therapy for chemotherapy-induced alopecia.
January 2022 in “UiTM Institutional Repositories (Universiti Teknologi MARA)” This study suggests that coffee ground extract may accelerate hair growth in rabbits, potentially due to its caffeine content.
July 2018 in “Media Informasi” This study found that a 3:2 combination of pandan leaf and mother-in-law's tongue extracts in hair tonic showed similar hair growth activity as 5% minoxidil after three weeks.
July 2026 in “Jurnal Multidisiplin Dehasen (MUDE)” In this study, hair tonic formulations containing moringa leaf extract and honey were tested for stability and found to remain stable and non-irritating after storage, meeting specific quality standards.
This study found that bitter melon leaf extract, particularly at a 10% concentration, promoted hair growth in male rabbits, outperforming the effect of a 2% minoxidil solution.
August 2024 in “Panggung Kebaikan” In this community service project, the researchers found that educating the public about using clove leaves as a herbal remedy for hair growth issues in Indonesia significantly increased public knowledge from 17.91% to 45.86%.
This study reported that a topical hair tonic containing a 7.5% talok leaf and 2% pare leaf extract combination promoted hair growth in female Wistar rats similarly to minoxidil, showing a 64.71% increase in hair growth with no significant difference from minoxidil in statistical analysis.
2 citations
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January 2015 in “Hair transplant forum international” This article discusses the introduction of human recombinant hyaluronidase in hair restoration surgery and presents no new clinical results.
This study found that adding menthol to Phyllanthus niruri ethanol extract gel enhanced hair growth and thickness in rats compared to the gel without menthol.