Hague: A New Mouse Hair Mutation With an Unstable Semidominant Allele

October 2002 in “ Genetics ”

Christophe Poirier, Atsushi Yoshiki, Kyoko Fujiwara, Jean‐Louis Guénet, Moriaki Kusakabe

hair mutation semidominant allele chromosome 15 keratin 2 complex genes skin

Studysummary This study mapped a spontaneous mouse hair mutation, "hague," to keratin genes on chromosome 15 but found no gene mutations in hague mice. Our plain-language summary of this paper — not a Tressless recommendation.

The study identified a spontaneous hair mutation in mice, called hague (Hag), which showed a semidominant inheritance pattern with incomplete penetrance in heterozygotes. The mutation was mapped to the telomeric region of chromosome 15 and was found to be unstable, sometimes shifting to a recessive pattern. Analysis of over 2000 meioses localized the mutation to the keratin 2 complex genes. A physical map of the critical region revealed a 600- to 800-kb segment with 14 genes, 11 of which were expressed in the skin, but none were mutated in the hague mice, leaving the specific causative mutation unidentified.

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