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    Glossary Vascularization

    process of forming new blood vessels in tissue

    Vascularization refers to the process by which new blood vessels form within a tissue. This is crucial for delivering oxygen and nutrients to tissues, promoting healing, and supporting the growth of new cells. In the context of hair and alopecia, proper vascularization of the scalp is essential for healthy hair growth, as it ensures that hair follicles receive the necessary nutrients and oxygen.

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    1. The Effects of Negative Pressure by External Tissue Expansion Device on Epithelial Cell Proliferation, Neo-Vascularization and Hair Growth in a Porcine Model PLoS ONE · 2016 · 16 citations
    2. 333 Poor perifollicular vascularization is associated with nutrient insufficiency and a quiescent metabolic phenotype in intermediate hair follicles from patients with female pattern hair loss Journal of Investigative Dermatology · 2021
    3. 3D multicellular micropatterning biomaterials for hair regeneration and vascularization Materials horizons · 2023 · 3 citations
    4. Vascularization of skin substitute constructed by vascular endothelial growth factor 165 gene-modified hair follicle stem cells compounded with three-dimensional gelatin-chondroitin sulfate-hyaluronic acid 2014
    5. Control of hair growth and follicle size by VEGF-mediated angiogenesis Journal of Clinical Investigation · 2001 · 520 citations
    6. Perifollicular vascularization: Cocultures and tricultures approaches to study the cross-talk between microvascular endothelial cells, follicle papilla cells and keratinocytes Vascular Pharmacology · 2015
    7. Hair Follicle–Derived Blood Vessels Vascularize Tumors in Skin and Are Inhibited by Doxorubicin Cancer Research · 2005 · 76 citations
    8. Thrombospondin-1 Plays a Critical Role in the Induction of Hair Follicle Involution and Vascular Regression During the Catagen Phase Journal of Investigative Dermatology · 2003 · 52 citations
    9. Conditioned media-integrated microneedles for hair regeneration through perifollicular angiogenesis Journal of Controlled Release · 2022 · 12 citations
    10. Preferential Crosstalk between Perifollicular Capillary Vessels and Dermal Papilla Cells during Hair Cycling Homeostasis Research Square (Research Square) · 2025
    11. Alterations in Hair Follicle Morphology and Hair Shaft Production After Follicular Unit Transplantation The American Journal of Dermatopathology · 2016 · 8 citations
    12. Angiopoietin-1 induces survival and proliferation of hair follicle dermal papilla cells through integrin α5β1 signaling Frontiers in Medicine · 2025
    13. Data Sheet 1_Angiopoietin-1 induces survival and proliferation of hair follicle dermal papilla cells through integrin α5β1 signaling.pdf OPAL (Open@LaTrobe) (La Trobe University) · 2025
    14. The effect and mechanism of Yangxue Shengfa Capsules on hair growth in mice Xiandai yaowu yu linchuang · 2010
    15. Scalp vascularization as a marker of topical minoxidil treatment efficacy in patients with androgenetic alopecia Postepy Dermatologii I Alergologii · 2021
    16. Paracrine crosstalk between human hair follicle dermal papilla cells and microvascular endothelial cells Experimental Dermatology · 2015 · 35 citations
    17. Vascular endothelial cells: Targets for studying the activity of hair follicle cell-produced VEGF Cell Biology and Toxicology · 1996 · 9 citations
    18. Effects of the biomimetic peptide Sh-Polypeptide 9 (CG-VEGF) on cocultures of human hair follicle dermal papilla cells and microvascular endothelial cells Experimental Dermatology · 2015 · 7 citations
    19. Tissue engineering of human hair follicles using a biomimetic developmental approach Nature Communications · 2018 · 184 citations
    20. Peppermint Oil Promotes Hair Growth without Toxic Signs Toxicological Research · 2014 · 30 citations
    21. From Hair to Cornea: Toward the Therapeutic Use of Hair Follicle-Derived Stem Cells in the Treatment of Limbal Stem Cell Deficiency Stem Cells · 2010 · 135 citations
    22. Transcriptome Sequencing Reveals Differences between Primary and Secondary Hair Follicle-derived Dermal Papilla Cells of the Cashmere Goat (Capra hircus) PLoS ONE · 2013 · 81 citations
    23. Impact of the Different Preparation Methods to Obtain Autologous Non-Activated Platelet-Rich Plasma (A-PRP) and Activated Platelet-Rich Plasma (AA-PRP) in Plastic Surgery: Wound Healing and Hair Regrowth Evaluation International Journal of Molecular Sciences · 2020 · 58 citations
    24. Gelatin-chondroitin-6-sulfate-hyaluronic acid scaffold seeded with vascular endothelial growth factor 165 modified hair follicle stem cells as a three-dimensional skin substitute Stem cell research & therapy · 2014 · 45 citations
    25. Angiogenin is expressed in human dermal papilla cells and stimulates hair growth Archives of dermatological research · 2008 · 20 citations
    26. Clinically applicable transplantation procedure of dermal papilla cells for hair follicle regeneration Journal of Tissue Engineering and Regenerative Medicine · 2011 · 15 citations
    27. The Angiogenic Potential of Mesenchymal Stem Cells from the Hair Follicle Outer Root Sheath Journal of Clinical Medicine · 2021 · 8 citations
    28. GDNF promotes hair formation and cutaneous wound healing by targeting bulge stem cells npj regenerative medicine · 2020 · 7 citations
    29. Mechanisms and clinical progress of adipose-derived stem cells and their derivatives in the treatment of hair loss Stem Cell Research & Therapy · 2025 · 3 citations
    30. Efficacy of a Nutritional Supplement, Standardized in Fatty Acids and Phytosterols, on Hair Loss and Hair Health in both Women and Men Journal of cosmetology & trichology · 2017 · 3 citations