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    Glossary Hair Follicle Degeneration

    gradual deterioration of structures producing hair, leading to thinning

    Hair Follicle Degeneration refers to the process where hair follicles, the tiny structures in the skin that produce hair, gradually deteriorate and lose their ability to function properly. This can lead to thinning hair or baldness and is often associated with conditions like alopecia or aging. For professionals, it involves changes at the cellular level, including reduced stem cell activity and alterations in the follicle's microenvironment.

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    1. Corneodesmosin gene ablation induces lethal skin-barrier disruption and hair-follicle degeneration related to desmosome dysfunction Journal of Cell Science · 2009 · 87 citations
    2. Inhibition of the development of metastatic squamous cell carcinoma in protein kinase C epsilon transgenic mice by alpha-difluoromethylornithine accompanied by marked hair follicle degeneration and hair loss. PubMed · 2003 · 26 citations
    3. Nanovesicles from Adipose Derived Stem Cells Delay Hair Follicle Degeneration and Stimulate Regeneration: a Novel Therapeutic Strategy for Androgenetic Alopecia Stem Cell Reviews and Reports · 2025
    4. Potential Application of Bioceramics in Promoting Hair Follicle Regeneration and Hair Growth Journal of Inorganic Materials · 2025
    5. The Dermal Papilla: An Instructive Niche for Epithelial Stem and Progenitor Cells in Development and Regeneration of the Hair Follicle Cold Spring Harbor Perspectives in Medicine · 2014 · 149 citations
    6. Therapeutic strategy for hair regeneration: hair cycle activation, niche environment modulation, wound-induced follicle neogenesis, and stem cell engineering Expert Opinion on Biological Therapy · 2013 · 74 citations
    7. Immune modulation of hair follicle regeneration npj Regenerative Medicine · 2020 · 29 citations
    8. Tissue Engineering and Regeneration of the Human Hair Follicle in Androgenetic Alopecia: Literature Review Life · 2022 · 4 citations
    9. Commensal microbiome promotes hair follicle regeneration by inducing keratinocyte HIF-1α signaling and glutamine metabolism Science Advances · 2023 · 1 citations
    10. Scaffolds for epithelial and hair follicle regeneration Elsevier eBooks · 2019 · 1 citations
    11. ROS-responsive hydrogel-delivered miR-665 targets STAT3 to alleviate inflammation and promote hair follicle regeneration in alopecia areata Journal of Nanobiotechnology · 2026
    12. Amine‐Functionalized Chitosan/dECM Composite Promotes Cutaneous Regeneration and Hair Follicle Activation by Regulating Oxidative Stress and Inflammation Advanced Healthcare Materials · 2025
    13. Stingless bee propolis promotes hair follicle regeneration and melanocyte function in chemotherapy-induced alopecia mouse model EXPERIMENTAL ANIMALS · 2025
    14. Emerging biomedical engineering strategies for hair follicle regeneration Bioactive Materials · 2025
    15. Functional regeneration strategies of hair follicles: advances and challenges Stem Cell Research & Therapy · 2025
    16. TLR9 activation in large wound induces tissue repair and hair follicle regeneration via γδT cells Cell Death and Disease · 2024
    17. Exosomes derived from mouse vibrissa dermal papilla cells promote hair follicle regeneration during wound healing by activating Wnt/β-catenin signaling pathway Journal of Nanobiotechnology · 2024
    18. Investigating the mechanisms underlying age-related dysfunctions in skin and hair follicle regeneration 2020
    19. Distribution pattern of some glycoconjugates of hair follicle regeneration in rat Clinical Biochemistry · 2011
    20. A novel and safe small molecule enhances hair follicle regeneration by facilitating metabolic reprogramming Experimental and Molecular Medicine · 2018 · 19 citations
    21. The Roles of Non-coding RNA in the Development and Regeneration of Hair Follicles: Current Status and Further Perspectives Frontiers in Cell and Developmental Biology · 2021 · 11 citations
    22. Bacterial cellulose/soybean protein isolate composites with promoted inflammation inhibition, angiogenesis and hair follicle regeneration for wound healing International Journal of Biological Macromolecules · 2022 · 4 citations
    23. Pathophysiological mechanisms of hair follicle regeneration and potential therapeutic strategies Stem Cell Research & Therapy · 2025
    24. Nanotechnology-based techniques for hair follicle regeneration Biomaterials · 2023
    25. 362 Not just a cell marker: DPP4 modulates regeneration of hair follicles in large wounds Journal of Investigative Dermatology · 2021
    26. Cells, growth factors and biomaterials used in tissue engineering for hair follicles regeneration Regenerative Therapy · 2022
    27. 755 Repurposing of DPP4 inhibition to improve hair follicle activation and regeneration Journal of Investigative Dermatology · 2022
    28. Wound-Induced Hair Follicle Neogenesis as a Promising Approach for Hair Regeneration Molecules and Cells · 2023
    29. iPSC-based approach for human hair follicle regeneration Frontiers in Cell and Developmental Biology · 2023
    30. Faculty Opinions recommendation of Live imaging of stem cell and progeny behaviour in physiological hair-follicle regeneration. Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2012