TLDR Human skin has less GDNF and its receptor with age.
The study investigated the age-related decline in Glial cell line-Derived Neurotrophic Factor (GDNF) and its receptor GFRα-1 in human skin, analyzing samples from 30 individuals across different age groups. Results showed a significant decrease in GDNF and GFRα-1 protein levels in the epidermis with aging, while their expression in the dermis remained strong. This decline was particularly notable in the stratum basale, stratum spinosum, and stratum granulare, with GFRα-1 being completely absent in the epidermis of elderly subjects. The findings suggested that diminished GDNF signaling might contribute to age-associated skin changes and hair follicle degeneration, highlighting the potential of GDNF and GFRα-1 as markers for aging and their possible roles in skin wound healing.
18 citations
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January 2008 in “Journal of The American Academy of Dermatology” Certain proteins and their receptors are more active during the growth phase of human hair and could be targeted to treat hair disorders.
16 citations
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November 2005 in “Journal of Clinical Pathology” CD1d expression in scalp skin and hair follicles changes with the hair cycle and may help protect against microbes.
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January 2008 in “Journal of The American Academy of Dermatology” Certain proteins and their receptors are more active during the growth phase of human hair and could be targeted to treat hair disorders.
1 citations
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April 2022 in “Regenerative Therapy” Activating the GDNF-GFRα1-RET signaling pathway could potentially promote skin and limb regeneration in humans and could be used to treat hair loss and promote wound healing.
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April 2024 in “Cells” Corneal cells can potentially revert to stem cells, aiding in repair and regeneration.
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April 2023 in “Veterinary sciences” Researchers found genes that may explain why some pigs grow winter hair, which could help breed cold-resistant pigs.
7 citations
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June 2020 in “npj regenerative medicine” GDNF helps grow hair and heal skin wounds by acting on hair stem cells.
