Age-Associated Decrease in GDNF and Its Cognate Receptor GFRα-1 Protein Expression in Human Skin

    June 2016 in “ International journal of experimental pathology ”
    Mohamed A. Adly, Hanan Assaf, Mahmoud R. Hussein
    TLDR Human skin has less GDNF and its receptor with age.
    The study investigated the age-related decline in Glial cell line-Derived Neurotrophic Factor (GDNF) and its receptor GFRα-1 in human skin, analyzing samples from 30 individuals across different age groups. Results showed a significant decrease in GDNF and GFRα-1 protein levels in the epidermis with aging, while their expression in the dermis remained strong. This decline was particularly notable in the stratum basale, stratum spinosum, and stratum granulare, with GFRα-1 being completely absent in the epidermis of elderly subjects. The findings suggested that diminished GDNF signaling might contribute to age-associated skin changes and hair follicle degeneration, highlighting the potential of GDNF and GFRα-1 as markers for aging and their possible roles in skin wound healing.
    Discuss this study in the Community →

    Research cited in this study

    1 / 1 results

    Related Community Posts Join

    1 / 1 results

      community Please explain this Minoxidil phenomena

      in Minoxidil  58 upvotes 1 year ago
      The post discusses the difference in effects of Minoxidil (Min) on scalp and facial hair. The user questions why Min-induced hair growth on the scalp is temporary, while facial hair growth seems permanent, even after stopping Min. They propose theories, including different Min mechanisms on body and facial hair, the role of DHT, and the possibility of not achieving fully terminal hair. The responses include personal experiences and theories about Min's effects on hair growth.

    Similar Research

    5 / 701 results