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    GlossaryBasal Layer (Stratum Basale)

    deepest epidermal layer where new skin cells form

    The Basal Layer, also known as the Stratum Basale, is the deepest layer of the epidermis, which is the outermost layer of the skin. This layer is crucial because it contains basal cells that continuously divide and push older cells towards the skin's surface, where they eventually shed. It also houses melanocytes, which produce the pigment melanin, giving skin its color and providing some protection against UV radiation.

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      learn Tretinoin

      the gold standard retinoid in dermatology that's also helpful for hair regrowth alongside Minoxidil

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      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 3 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Why do I see so many people here recommend microneedling?

      in Microneedling  108 upvotes 1 year ago
      The efficacy of microneedling for hair regrowth as either a stand-alone therapy or adjunct to Minoxidil, and whether Tretinoin is a safer and more effective option. Replies include personal accounts from users who have had success with microneedling in combination with minoxidil and peptide serums, as well as considerations of technique, depth, and potential scarring.

      community Dr Kyle Gillett on topical Dutasteride

      in Finasteride/Dutasteride  56 upvotes 1 year ago
      The potential effectiveness of topical dutasteride, as well as other hair loss treatments such as finasteride, RU58841, minoxidil, and various vitamins. Experiences from users who have used these treatments were shared.

      community microneedle, any long term users damage?

      in Microneedling  35 upvotes 5 months ago
      Microneedling is effective for hair growth, especially when combined with finasteride and minoxidil, but concerns exist about potential long-term skin damage. Users report increased collagen and elastin deposition, but the long-term effects on the scalp remain uncertain.

      community Trying to regrow crown been on Fin for 4.5 years

      in Finasteride/Dutasteride  6 upvotes 6 months ago
      The user has been on finasteride for 4.5 years and minoxidil for 10 years, maintaining hair but not regrowing much on the crown and temples. They are considering using a dermastamp more frequently and possibly trying RU58841, but are hesitant about dutasteride due to concerns about side effects and DHT suppression.