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Glossary Hair Cell Loss

degeneration or death of sensory cells in the inner ear

Hair Cell Loss refers to the degeneration or death of hair cells, which are specialized sensory cells found in the inner ear and responsible for detecting sound and maintaining balance. This condition can lead to hearing loss and balance disorders. In the context of the scalp, it can also refer to the loss of hair follicles, leading to conditions like alopecia.

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Research

5 / 1000+ results

research Chemical Screening for Hair Cell Loss and Protection in the Zebrafish Lateral Line

114 citations , March 2010 in “Zebrafish”

This review discusses the use of the zebrafish lateral line system as a model to study hair cell loss, protection, and regeneration, with potential implications for human hearing research.

research Defining the Cellular Environment in the Organ of Corti following Extensive Hair Cell Loss: A Basis for Future Sensory Cell Replacement in the Cochlea

71 citations , January 2012 in “PloS one”

This study observed that after hair cell loss in the mouse cochlea, supporting cells were replaced by migrating non-specialised cells, with genetic background affecting the rate of tissue re-organization.

research Molecular basis of hair cell loss

66 citations , February 2015 in “Cell & tissue research/Cell and tissue research”

This review explores the mechanisms of hair cell death due to factors like noise, ototoxic drugs, and aging and reports no conclusive clinical results; ongoing research may eventually enable preventive treatments for hearing loss.

research CFTR potentiator ivacaftor protects against noise-induced hair cell loss by increasing Nrf2 and reducing oxidative stress

4 citations , August 2023 in “Biomedicine & Pharmacotherapy”

This study found that in noise-exposed FVB/NJ mice and cell models, ivacaftor reduced oxidative stress and hearing damage by maintaining CFTR function and increasing Nrf2 expression, suggesting its potential for treating noise-induced hearing loss.

research Calcium channel inhibitor and extracellular calcium improve aminoglycoside-induced hair cell loss in zebrafish

April 2024 in “Archives of toxicology”

Certain substances can protect against ear damage from some antibiotics in zebrafish.

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Community Join

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community Cell senescence-targeted treatment for hair loss, has anyone tried any products/enzymes etc. that use this theory

5 upvotes 1 year ago

DHT causes hair loss by driving cells into senescence, and a polyphenol in black chokeberry may reverse this. A product using this theory is being considered for use alongside finasteride, minoxidil, and microneedling.

community Stem cell-grown hair could help those with hair loss

12 upvotes 11 years ago

Stem cell-grown hair could potentially help those with hair loss. Treatments discussed include Minoxidil, finasteride, and RU58841.

community Looking for stem cell regrowth options combatting hair loss - German startup seems interesting??

8 upvotes 3 years ago

A German startup, Mane Biotech, developed a head wearable device to reactivate hair follicle stem cells, sparking skepticism among users. Some users suspect it might be a scam, while others are interested in more information from the company's newsletter.

community 42F: Has anyone tried stem-cell injections for hair loss? How was that?

in Female 4 upvotes 4 weeks ago

A 42-year-old woman is exploring stem-cell and exosome treatments for hair loss, seeking personal experiences from others. Responses suggest these treatments have mediocre results, with minoxidil being recommended as more effective for women.

community A cure for baldness? Stem cell researchers race to regenerate follicles from hair resistant to loss

23 upvotes 12 years ago

Researchers are working on regenerating hair follicles using stem cells, but a cure for baldness is still years away. Current treatments mentioned include Minoxidil, finasteride, and RU58841.

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Learn

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learn Stem Cell Factor

Can stem cell factor be combined with other topical hair loss solutions? No published human trial has tested topical stem cell factor alongside minoxidil or other established treatments, so neither the safety nor the benefit of the combination has been established. Community users report layering these products, but that is anecdote rather than clinical evidence.

learn Hair Transplant

Can a hair transplant be combined with other treatments? Clinics commonly say a transplant is combined with other treatments, most often minoxidil, finasteride or PRP, but the evidence behind each add-on differs. Some of the add-ons offered, such as stem-cell or exosome products, are not approved treatments for hair loss.
Can PRP be combined with a hair transplant? Providers routinely offer PRP alongside a hair transplant and most say it speeds healing and supports graft survival; the published human studies are small and mixed, so the size of any benefit is unsettled.
Is a hair transplant permanent? Transplanted hair is generally permanent but requires ongoing care to maintain results.

learn procapil

Want to stop hormonal hair loss without touching your hormone levels? Procapil could block the enzyme doing the damage. Procapil's supplier describes it as inhibiting 5-alpha reductase at the scalp without changing hormone levels, but the published support is cell and animal work plus one small human study of a caffeine-plus-Procapil formula. It is a cosmetic ingredient, not an approved hair-loss treatment, and no trial has compared it with finasteride or minoxidil.

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Alopecia Areata

autoimmune disorder causing patchy hair loss

learn Hair Multiplication

extract, clone, and reinsert your own hair cells

learn Stemoxydine

chemical from L'Oreal that encourages hair to enter growth phase

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Clinics

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Experts

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Unscored
SMP Specialist
Hairo Fallas
Newark, NJ, United States

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Hairo Fallas