TLDR PROTO1 and PROTO2 protect against hearing damage.
The study used the zebrafish lateral line system to screen for compounds that induce or protect against hair cell loss, identifying 21 compounds that caused hair cell death and two compounds, PROTO1 and PROTO2, that protected against neomycin-induced damage. These findings demonstrated the zebrafish model's potential for identifying ototoxic drugs and protective agents, suggesting clinical applications for hearing protection. The research emphasized the need for standardized drug screening to prevent hearing loss and further exploration of drug delivery methods and protective pathways.
34 citations,
February 2015 in “Frontiers in Cellular Neuroscience” Zebrafish helped find new ways to prevent drug-induced hair cell death and potential treatments for hearing loss.
66 citations,
February 2015 in “Cell & tissue research/Cell and tissue research” The document concludes that there are no effective clinical treatments for hearing loss due to hair cell damage, but research is ongoing.
44 citations,
March 2016 in “Frontiers in cellular neuroscience” Some natural compounds can protect fish ear cells from damage by certain antibiotics without affecting the antibiotics' ability to fight infections.
4 citations,
December 2022 in “Frontiers in cell and developmental biology” Zebrafish larvae are used to study and find treatments for ear cell damage because they are easier to observe and test than mammals.
September 2022 in “Research Square (Research Square)” Increasing Rps14 helps grow more inner ear cells and repair hearing cells in baby mice.
